Programmed Degradation of Hydrogels with a Double-Locked Domain

Jinping Lai, Lidya Abune, Nan Zhao, Yong Wang

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The ability to control the degradation of a material is critical to various applications. The purpose of this study was to demonstrate a concept of controlling degradation by using a double-locked domain (DLD). DLDs are molecular structures with two functional units that work cooperatively under environmental stimulation. One unit is triggered to transform without cleavage in the presence of the first stimulus, but this transformation enables the activation of the other unit for cleavage in the presence of the second stimulus. A DLD is presented that is activated to transform through intramolecular reconfiguration when exposed to light. After this transformation, the light-triggered DLD can undergo rapid cleavage under acid treatment. When this DLD is used as the crosslinkers of hydrogels, hydrogels undergo rapid degradation after sequential exposure to light irradiation and acid treatment. Reversing the order of light irradiation and acid treatment or only using individual stimulation does not lead to comparable degradation. Thus, this study has successfully demonstrated the great potential of using DLDs to achieve programmable degradation of materials.

Original languageEnglish (US)
Pages (from-to)2820-2825
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number9
StatePublished - Feb 25 2019

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry


Dive into the research topics of 'Programmed Degradation of Hydrogels with a Double-Locked Domain'. Together they form a unique fingerprint.

Cite this