Progression of CKD and Uremic Symptoms

Gurwant Kaur, Vikram Patney

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Chronic kidney disease (CKD) is a global health problem and its progression is inevitable. The CKD and its progression to end-stage renal disease (ESRD) needing renal replacement therapy (RRT) contribute significantly to the morbidity and mortality of our patients. The progression of CKD follows a nonlinear trajectory of decline in glomerular filtration rate (GFR) based on the presence of comorbidities and health events in an individual’s life along with the effect of medications and environmental factors. Early detection and interventions to control the contributing factors play a vital role in halting the progression of CKD. It is distressing for patients and their families to conceptualize the effects of CKD, especially when they are asymptomatic. Chronic interstitial inflammation, fibrosis, and tubular atrophy are the main pathological findings. Inflammatory markers play a major role in the pathogenesis of CKD along with chronic renin-angiotensin-aldosterone system (RAAS) activation.

Original languageEnglish (US)
Title of host publicationApproaches to Chronic Kidney Disease
Subtitle of host publicationA Guide for Primary Care Providers and Non-Nephrologists
PublisherSpringer International Publishing
Pages69-85
Number of pages17
ISBN (Electronic)9783030830823
ISBN (Print)9783030830816
DOIs
StatePublished - Jan 1 2021

All Science Journal Classification (ASJC) codes

  • General Medicine

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