Abstract
Chronic kidney disease (CKD) is a global health problem and its progression is inevitable. The CKD and its progression to end-stage renal disease (ESRD) needing renal replacement therapy (RRT) contribute significantly to the morbidity and mortality of our patients. The progression of CKD follows a nonlinear trajectory of decline in glomerular filtration rate (GFR) based on the presence of comorbidities and health events in an individual’s life along with the effect of medications and environmental factors. Early detection and interventions to control the contributing factors play a vital role in halting the progression of CKD. It is distressing for patients and their families to conceptualize the effects of CKD, especially when they are asymptomatic. Chronic interstitial inflammation, fibrosis, and tubular atrophy are the main pathological findings. Inflammatory markers play a major role in the pathogenesis of CKD along with chronic renin-angiotensin-aldosterone system (RAAS) activation.
Original language | English (US) |
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Title of host publication | Approaches to Chronic Kidney Disease |
Subtitle of host publication | A Guide for Primary Care Providers and Non-Nephrologists |
Publisher | Springer International Publishing |
Pages | 69-85 |
Number of pages | 17 |
ISBN (Electronic) | 9783030830823 |
ISBN (Print) | 9783030830816 |
DOIs | |
State | Published - Jan 1 2021 |
All Science Journal Classification (ASJC) codes
- General Medicine