TY - JOUR
T1 - Progressive osteosclerosis and visceral calcification after cord blood transplantation
AU - Asada, Noboru
AU - Ishii, Shinichi
AU - Wakahashi, Kanako
AU - Kawano, Hiroki
AU - Kawamori, Yuriko
AU - Nishikawa, Shinichiro
AU - Minagawa, Kentaro
AU - Okamura, Atsuo
AU - Shimoyama, Manabu
AU - Katayama, Yoshio
AU - Hayashi, Yoshitake
AU - Itoh, Tomoo
AU - Tanimoto, Mitsune
AU - Matsui, Toshimitsu
PY - 2010/4
Y1 - 2010/4
N2 - A 26-year-old woman, who successfully underwent umbilical cord blood transplantation for aplastic anemia 4 years previously, had suffered from hepatosplenic microabscesses caused by unidentifiable grocott stain-positive spores from immediately after the transplantation. At 51 months post-transplant, we attempted bone marrow biopsy from her posterior iliac crest, but failed to penetrate the cortical bone. X-ray of her spine and pelvis showed marked and diffuse osteosclerosis. Retrospective analysis of computed tomography revealed the gradual replacement of sternal, vertebral, and pelvic bone marrow with calcified tissues in addition to the dispersed calcification of the liver, spleen, and kidneys over the last 2 years. The bone mineral density of the lumbar spine had increased but not that of the femoral neck. Biomedical parameters for bone remodeling demonstrated enhanced bone formation as well as bone resorption and secondary hyperparathyroidism. Based on the past reports, we suggest that chronic fungal infection, which caused visceral calcification, induced the production of humoral factors for osteoblastic activation.
AB - A 26-year-old woman, who successfully underwent umbilical cord blood transplantation for aplastic anemia 4 years previously, had suffered from hepatosplenic microabscesses caused by unidentifiable grocott stain-positive spores from immediately after the transplantation. At 51 months post-transplant, we attempted bone marrow biopsy from her posterior iliac crest, but failed to penetrate the cortical bone. X-ray of her spine and pelvis showed marked and diffuse osteosclerosis. Retrospective analysis of computed tomography revealed the gradual replacement of sternal, vertebral, and pelvic bone marrow with calcified tissues in addition to the dispersed calcification of the liver, spleen, and kidneys over the last 2 years. The bone mineral density of the lumbar spine had increased but not that of the femoral neck. Biomedical parameters for bone remodeling demonstrated enhanced bone formation as well as bone resorption and secondary hyperparathyroidism. Based on the past reports, we suggest that chronic fungal infection, which caused visceral calcification, induced the production of humoral factors for osteoblastic activation.
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U2 - 10.1007/s12185-010-0524-x
DO - 10.1007/s12185-010-0524-x
M3 - Article
C2 - 20162469
AN - SCOPUS:77950917835
SN - 0925-5710
VL - 91
SP - 542
EP - 545
JO - International journal of hematology
JF - International journal of hematology
IS - 3
ER -