TY - JOUR
T1 - Projections of the parabrachial nucleus in the Old World monkey
AU - Pritchard, Thomas C.
AU - Hamilton, Robert B.
AU - Norgren, Ralph
N1 - Funding Information:
We thank Ms. Irma Cardinale and Ms. Lauren Adasko for their technical assistance with the histology. Ms. Joan Bernardo and Ms. Kathleen Smith provided clerical assistance with the manuscript. We also are indebted to Mr. Greg Young, whose expertise with computer graphics is evident in the artwork of this paper. Drs. Robert Beckstead and Joel Morse assisted with several of the early surgeries; they each have our thanks. Preliminary results have been published previously in abstract form (92). This research was supported in part by grants from the Public Health Service (DC00246), the National Science Foundation (BNS80-06444), and the American Heart Association, South Central Pennsylvania Chapter. Dr. Nor-gren is a recipient of a Research Scientist Award from the National Institute of Mental Health (MH 00653).
PY - 2000
Y1 - 2000
N2 - The efferent projections of the pontine parabrachial nucleus (PBN) were examined in the Old World monkey (Macaca fascicularis) using tritiated amino acid autoradiography and horseradish peroxidase histochemistry. Parabrachiofugal fibers ascended to the forebrain along three pathways: the central tegmental tract, the ventral ascending catecholaminergic pathway, and a pathway located on the midline between the medial longitudinal fasciculi. The PBN projected heavily to the central nucleus of the amygdala and the lateral division of the bed nucleus of the stria terminalis and moderately to the ventral tegmental area and the substantia nigra. Light terminal label also was present within the dorsomedial, ventromedial, lateral, supramammillary, and infundibular nuclei of the hypothalamus and the annular nucleus and the dorsal raphe nucleus within the brain stem. The overall pattern of terminal label was similar to that previously reported for nonprimate species, but several differences were notable. In monkey the projection to the ventrobasal thalamus did not coincide with the region that contains gustatory-responsive neurons. In rats, these parabrachiothalamic fibers convey gustatory activity but in the monkey these fibers may carry visceral afferent information. The projections from the PBN to the hypothalamus in the monkey were neither as widespread nor as intense as in the rat, and the monkey lacks a projection from the PBN to the frontal and insular cortices. (C) 2000 Academic Press.
AB - The efferent projections of the pontine parabrachial nucleus (PBN) were examined in the Old World monkey (Macaca fascicularis) using tritiated amino acid autoradiography and horseradish peroxidase histochemistry. Parabrachiofugal fibers ascended to the forebrain along three pathways: the central tegmental tract, the ventral ascending catecholaminergic pathway, and a pathway located on the midline between the medial longitudinal fasciculi. The PBN projected heavily to the central nucleus of the amygdala and the lateral division of the bed nucleus of the stria terminalis and moderately to the ventral tegmental area and the substantia nigra. Light terminal label also was present within the dorsomedial, ventromedial, lateral, supramammillary, and infundibular nuclei of the hypothalamus and the annular nucleus and the dorsal raphe nucleus within the brain stem. The overall pattern of terminal label was similar to that previously reported for nonprimate species, but several differences were notable. In monkey the projection to the ventrobasal thalamus did not coincide with the region that contains gustatory-responsive neurons. In rats, these parabrachiothalamic fibers convey gustatory activity but in the monkey these fibers may carry visceral afferent information. The projections from the PBN to the hypothalamus in the monkey were neither as widespread nor as intense as in the rat, and the monkey lacks a projection from the PBN to the frontal and insular cortices. (C) 2000 Academic Press.
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U2 - 10.1006/exnr.2000.7450
DO - 10.1006/exnr.2000.7450
M3 - Article
C2 - 10964489
AN - SCOPUS:0033826298
SN - 0014-4886
VL - 165
SP - 101
EP - 117
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -