Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

Megumi Kishimoto-Urata, Shinji Urata, Ryoji Kagoya, Fumiaki Imamura, Shin Nagayama, Rachel A. Reyna, Junki Maruyama, Tatsuya Yamasoba, Kenji Kondo, Sanae Hasegawa-Ishii, Slobodan Paessler

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.

Original languageEnglish (US)
Article number5728
JournalScientific reports
Volume12
Issue number1
DOIs
StatePublished - Dec 2022

All Science Journal Classification (ASJC) codes

  • General

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