Prostaglandin production in chronic progressive multiple sclerosis

Judith A. Aberg; Laurence M. Demers; Paula J. Romano; Richard B. Tenser

doi:10.1002/jcla.1860040403

Prostaglandin production in chronic progressive multiple sclerosis

Judith A. Aberg, Laurence M. Demers, Paula J. Romano, Richard B. Tenser

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E₂ (PGE₂) and thromboxane B₂ (TxB₂) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE₂ in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB₂release were noted between the three groups.

Original language	English (US)
Pages (from-to)	246-250
Number of pages	5
Journal	Journal of Clinical Laboratory Analysis
Volume	4
Issue number	4
DOIs	https://doi.org/10.1002/jcla.1860040403
State	Published - 1990

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Hematology
Public Health, Environmental and Occupational Health
Clinical Biochemistry
Medical Laboratory Technology
Biochemistry, medical
Microbiology (medical)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jcla.1860040403

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title = "Prostaglandin production in chronic progressive multiple sclerosis",

abstract = "Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE2 in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB2release were noted between the three groups.",

author = "Aberg, {Judith A.} and Demers, {Laurence M.} and Romano, {Paula J.} and Tenser, {Richard B.}",

year = "1990",

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T1 - Prostaglandin production in chronic progressive multiple sclerosis

AU - Aberg, Judith A.

AU - Demers, Laurence M.

AU - Romano, Paula J.

AU - Tenser, Richard B.

PY - 1990

Y1 - 1990

N2 - Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE2 in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB2release were noted between the three groups.

AB - Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE2 in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB2release were noted between the three groups.

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JO - Journal of Clinical Laboratory Analysis

JF - Journal of Clinical Laboratory Analysis

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ER -

Prostaglandin production in chronic progressive multiple sclerosis

Abstract

All Science Journal Classification (ASJC) codes

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