TY - JOUR
T1 - Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats
AU - Wu, Zheng
AU - Xu, Qi
AU - Zhang, Lei
AU - Kong, Dehu
AU - Ma, Rong
AU - Wang, Liecheng
N1 - Funding Information:
Acknowledgments We thank Prof. Y. Shen and Mr. D. Huang for technical assistance and Dr. S. R. Wang for critical comments on the manuscript. This study was supported by grants from the Grants for Scientific Research of BSKY (XJ2005006) from Anhui Medical University, the Excellent Talent of Anhui province of China (06043090), the National Century Excellent Talents in University of China (NCET-06-0557) to L. Wang, and Natural Science Foundation of Anhui Province Department of Education (NSFA KJ2007A028) to D. Kong.
PY - 2009/8
Y1 - 2009/8
N2 - Resveratrol (Res) is a phytoalexin produced naturally by several plants, which has multi functional effects such as neuroprotection, anti-inflammatory, and anti-cancer. The present study was to evaluate a possible anti-epileptic effect of Res against kainate-induced temporal lobe epilepsy (TLE) in rat. We performed behavior monitoring, intracranial electroencepholography (IEEG) recording, histological analysis, and Western blotting to evaluate the anti-epilepsy effect of Res in kainate-induced epileptic rats. Res decreased the frequency of spontaneous seizures and inhibited the epileptiform discharges. Moreover, Res could protect neurons against kainate-induced neuronal cell death in CA1 and CA3a regions and depressed mossy fiber sprouting, which are general histological characteristics both in TLE patients and animal models. Western blot revealed that the expression level of kainate receptors (KARs) in hippocampus was reduced in Res-administrated rats compared to that in epileptic ones. These results suggest that Res is a potent anti-epilepsy agent, which protects against epileptogenesis and progression of the kainate-induced TLE animal.
AB - Resveratrol (Res) is a phytoalexin produced naturally by several plants, which has multi functional effects such as neuroprotection, anti-inflammatory, and anti-cancer. The present study was to evaluate a possible anti-epileptic effect of Res against kainate-induced temporal lobe epilepsy (TLE) in rat. We performed behavior monitoring, intracranial electroencepholography (IEEG) recording, histological analysis, and Western blotting to evaluate the anti-epilepsy effect of Res in kainate-induced epileptic rats. Res decreased the frequency of spontaneous seizures and inhibited the epileptiform discharges. Moreover, Res could protect neurons against kainate-induced neuronal cell death in CA1 and CA3a regions and depressed mossy fiber sprouting, which are general histological characteristics both in TLE patients and animal models. Western blot revealed that the expression level of kainate receptors (KARs) in hippocampus was reduced in Res-administrated rats compared to that in epileptic ones. These results suggest that Res is a potent anti-epilepsy agent, which protects against epileptogenesis and progression of the kainate-induced TLE animal.
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U2 - 10.1007/s11064-009-9920-0
DO - 10.1007/s11064-009-9920-0
M3 - Article
C2 - 19219549
AN - SCOPUS:67349091742
SN - 0364-3190
VL - 34
SP - 1393
EP - 1400
JO - Neurochemical Research
JF - Neurochemical Research
IS - 8
ER -
