Protein-O-carboxylmethyltransferase in the rat brain: High regional levels in the substantia nigra, locus coeruleus and paraventricular nucleus

Immunocytochemical techniques were used to localize protein-O-carboxylmethyltransferase in the rat brain. Particularly high levels of immunoreactive protein-O-carboxylmethyltransferase were found in the paraventricular and supraoptic nucleus, the substantia nigra and the locus coeruleus. The enhanced expression of the methyltransferase in these brain regions suggests that protein carboxylmethylation is of particular importance in these areas. These findings are consistent with previous biochemical studies which suggest that protein methylation plays a role in presynaptic monoaminergic neurons and in the release and/or processing of neurohypophyseal peptides.