Provocation of Nonepileptic Seizures by Suggestion in a General Seizure Population

C. W. Bazil, M. Kothari, D. Luciano, J. Moroney, S. Song, B. Vasquez, H. J. Weinreb, O. Devinsky

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66 Scopus citations


Summary: Nonepileptic seizures (NES) are common and are often diagnosed at epilepsy centers by video‐EEG recording of both spontaneous and suggestion‐induced episodes, but no study has evaluated provocative testing in a general seizure population. We studied consecutive patients with a tentative diagnosis of epilepsy using saline provocation during video–EEG recording, suggesting that this could produce a typical seizure. Of 52 patients, 40% had no response, 23% had responses unlike their seizures, and 37% had typical episodes (positive test). Patients whose usual episodes resembled complex partial seizures (CPS) were more likely to have NES than were patients with a history of generalized tonic‐clonic seizures (GTC). Of patients with positive provocations, the primary physician predicted NES in 68% of cases. This preliminary study suggests that NES are frequent in a general neurology setting, and that saline provocation is a sensitive method of identifying NES.

Original languageEnglish (US)
Pages (from-to)768-770
Number of pages3
Issue number4
StatePublished - Jul 1994

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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