TY - JOUR
T1 - Psychosexual behavior in hypopituitary men
T2 - A controlled comparison of gonadotropin and testosterone replacement
AU - Clopper, Richard R.
AU - Voorhess, Mary L.
AU - MacGillivray, Margaret H.
AU - Lee, Peter A.
AU - Mills, Barbara
N1 - Funding Information:
Supported in part by USPHS Grant HD-19760, NIH General Clinical Research Center Grant RR-00084, and funds from the Children's Growth Foundation, Buffalo, NY.
PY - 1993
Y1 - 1993
N2 - Nine gonadotropin-deficient hypopituitary men were cycled through periods of treatment with testosterone (T), gonadotropin (Gn), and placebo (Pl) using a blind cross-over design. Self-reports of sexual behavior, recordings of nocturnal penile tumescence (NPT), and sex steroid levels were obtained during each treatment period. Subjects had significantly higher plasma T during the T and Gn treatments than during the control periods. Similarly, self-reported frequency of ejaculation and ratings of libido as well as duration measures of NPT were significantly higher on T and Gn. Two thirds of the sample had no sociosexual experience. Behavioral differences between the T and Gn periods were minimal. These data support the hypothesis that Gn and T are equally effective in stimulating specific aspects of male psychosexual behavior.
AB - Nine gonadotropin-deficient hypopituitary men were cycled through periods of treatment with testosterone (T), gonadotropin (Gn), and placebo (Pl) using a blind cross-over design. Self-reports of sexual behavior, recordings of nocturnal penile tumescence (NPT), and sex steroid levels were obtained during each treatment period. Subjects had significantly higher plasma T during the T and Gn treatments than during the control periods. Similarly, self-reported frequency of ejaculation and ratings of libido as well as duration measures of NPT were significantly higher on T and Gn. Two thirds of the sample had no sociosexual experience. Behavioral differences between the T and Gn periods were minimal. These data support the hypothesis that Gn and T are equally effective in stimulating specific aspects of male psychosexual behavior.
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U2 - 10.1016/0306-4530(93)90066-T
DO - 10.1016/0306-4530(93)90066-T
M3 - Article
C2 - 8493299
AN - SCOPUS:0027461578
SN - 0306-4530
VL - 18
SP - 149
EP - 161
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
IS - 2
ER -
