Pulling Forces Differentially Affect Refolding Pathways Due to Entangled Misfolded States in SARS-CoV-1 and SARS-CoV-2 Receptor Binding Domain

Keyphrases

• Pulling Force 100%
• Misfolded States 100%
• SARS-CoV-2 Receptor Binding Domain 100%
• SARS-CoV-1 100%
• Bell 80%
• External Force 60%
• Piconewton 60%
• Entanglement 40%
• Misfolding 40%
• Unfolding Method 20%
• Native State 20%
• Slowing down 20%
• Non-native 20%
• Coarse-grained Molecular Dynamics Simulation 20%
• Trap States 20%
• Small Force 20%
• Folded Conformation 20%
• Protein Refolding 20%
• Folding Time 20%
• Receptor Binding Domain 20%
• Force Applied 20%

Chemistry

• Spectroscopy 100%
• Molecular Dynamics Simulation 100%
• Protein Refolding 100%

Neuroscience

• Receptor Binding 100%
• SARS Coronavirus 100%
• Behavior (Neuroscience) 11%
• Spectroscopy 11%
• Protein Refolding 11%