Pulse voltammetry with microvoltammetric electrodes

A. G. Ewing, M. A. Dayton, R. M. Wightman

Research output: Contribution to journalArticlepeer-review

206 Scopus citations


Microvoltammetric electrodes can be used to provide reproducible results In an extremely complex chemical medium, the mammalian brain. Because of the small size of the microelectrodes, current on the back step of a chronoamperometrlc experiment is essentially nonfaradalc and can be used for residual current correction. The use of normal pulse voltammetry minimizes electrode response deterioration caused by filming of the electrode surface by electrogenerated products. The response of these electrodes In vivo is superior to that of other electrodes; It Is not altered by the repetition rate of the potential pulses, and dopamine, a compound of prime neurochemical Interest, can be partially resolved from ascorbic acid and dlhydroxyphenylacetlc acid by In vivo voltammetry.

Original languageEnglish (US)
Pages (from-to)1842-1847
Number of pages6
JournalAnalytical Chemistry
Issue number12
StatePublished - Oct 1981

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry


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