QTLs for general cognitive ability in children: DNA pooling for chromosome 22

L. Hill, P. Asherson, D. Ball, I. Craig, J. Daniels, T. Eley, B. Freeman, T. Ninomiya, P. Fisher, D. Turic, N. Williams, M. Chorney, K. Chorney, D. Lubinski, C. Benbow, L. A. Thompson, D. K. Detterman, M. J. Owen, P. McGuffin, R. Plomin

Research output: Contribution to journalArticlepeer-review


General cognitive ability, often indexed by IQ tests, is one of the most highly heritable quantitative behavioral traits relevant to cognitive neuroscience. The IQ QTL Project uses an allelic association strategy to focus on high ability rather than disability and a more systematic approach to association using a dense genome-wide map of markers and DNA pooling. The purpose of the present study was to apply DNA pooling to 75 markers on chromosome 22 (average interval 1 cM) for an original high IQ sample (N = 51, average IQ = 136) and an average IQ control group (N = 51, average IQ = 103). Tentative QTL associations, as indexed by delta-AIP, in the original sample are subjected to replication, again using DNA pooling, with an extremely high IQ group (N = 52, IQ >160) and an independent control group (N = 50, average IQ = 101). Using a lenient criterion (delta-AIP > 0.2), 13 markers of interest were identified in the original sample; DNA pooling with these markers is underway in the replication sample. Markers that survive replication will then be individually genotyped for all subjects, enabling comparisons with the pooled results. This research demonstrates the usefulness of DNA pooling for a systematic genome scan in the analysis of complex quantitative traits.

Original languageEnglish (US)
Pages (from-to)486
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number6
StatePublished - Nov 6 1998

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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