Abstract
Flow cytometry is a multiparameter single-cell assay ubiquitous in HIV/AIDS clinical and research settings for evaluating the immune response to the virus, therapy, and vaccination. In clinical practice, flow cytometry is used to monitor the CD4 and CD8 T cell counts of HIV-infected subjects. In research settings, flow cytometry is used to evaluate innate and antigen-specific responses to the HIV virus, so as to better understand pathogenesis, the mechanisms responsible for long-term nonprogression, and to develop effective immune-based interventions. In vaccine development, there is significant interest in the potential of flow-based biomarkers that can serve as surrogate measures of efficacy.
Original language | English (US) |
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Title of host publication | Quantitative Methods for HIV/AIDS Research |
Publisher | CRC Press |
Pages | 135-156 |
Number of pages | 22 |
ISBN (Electronic) | 9781498734257 |
ISBN (Print) | 9781498734233 |
DOIs | |
State | Published - Jan 1 2017 |
All Science Journal Classification (ASJC) codes
- Mathematics(all)
- Medicine(all)