Quantitative Trait Loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice

Dean H. Lang; Glenn S. Gerhard; James W. Griffith; George P. Vogler; David J. Vandenbergh; David A. Blizard; Joseph T. Stout; Joan M. Lakoski; Gerald E. McClearn

doi:10.1007/BF03324809

Quantitative Trait Loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice

Dean H. Lang, Glenn S. Gerhard, James W. Griffith, George P. Vogler, David J. Vandenbergh, David A. Blizard, Joseph T. Stout, Joan M. Lakoski, Gerald E. McClearn

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background and aims: Genes associated with longevity have been identified using both single gene and genome-wide approaches in a variety of species. The aim of this study was to identify quantitative trait loci (QTLs) that influence longevity in male and female mice from twenty-three C57BL/6J by DBA/2J (BXD) recombinant inbred (RI) strains. Methods: Approximately 12 animals of each sex for each RI strain were maintained under standard conditions until natural death or moribundity criteria were met. Results: A number of life span-relevant loci previously reported on chromosomes (Chrs) 7, 8, 10 and 11 were confirmed. In addition, 5 previously unreported QTLs for mouse life span on Chrs 1,2,6,11, and X were identified as significant and 3 QTLs on Chrs 5, 8, and 16 were suggestive. Conclusions: Several QTLs were coincident in males and females although the modest correlation between male and female median lifespans and the identification of sex specific QTLs provide evidence that the genetic architecture underlying longevity in the sexes may differ substantially. The identification of multiple QTLs for longevity will provide valuable resources for both reductionist and integrationist research into mechanisms of life span determination.

Original language	English (US)
Pages (from-to)	8-19
Number of pages	12
Journal	Aging Clinical and Experimental Research
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/BF03324809
State	Published - Feb 2010

All Science Journal Classification (ASJC) codes

Aging
Geriatrics and Gerontology

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10.1007/BF03324809

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title = "Quantitative Trait Loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice",

abstract = "Background and aims: Genes associated with longevity have been identified using both single gene and genome-wide approaches in a variety of species. The aim of this study was to identify quantitative trait loci (QTLs) that influence longevity in male and female mice from twenty-three C57BL/6J by DBA/2J (BXD) recombinant inbred (RI) strains. Methods: Approximately 12 animals of each sex for each RI strain were maintained under standard conditions until natural death or moribundity criteria were met. Results: A number of life span-relevant loci previously reported on chromosomes (Chrs) 7, 8, 10 and 11 were confirmed. In addition, 5 previously unreported QTLs for mouse life span on Chrs 1,2,6,11, and X were identified as significant and 3 QTLs on Chrs 5, 8, and 16 were suggestive. Conclusions: Several QTLs were coincident in males and females although the modest correlation between male and female median lifespans and the identification of sex specific QTLs provide evidence that the genetic architecture underlying longevity in the sexes may differ substantially. The identification of multiple QTLs for longevity will provide valuable resources for both reductionist and integrationist research into mechanisms of life span determination.",

author = "Lang, {Dean H.} and Gerhard, {Glenn S.} and Griffith, {James W.} and Vogler, {George P.} and Vandenbergh, {David J.} and Blizard, {David A.} and Stout, {Joseph T.} and Lakoski, {Joan M.} and McClearn, {Gerald E.}",

note = "Funding Information: This work was supported by grants P01 AG14731 and training grant AG00276 from the National Institute on Aging of the National Institutes of Health.",

year = "2010",

month = feb,

doi = "10.1007/BF03324809",

language = "English (US)",

volume = "22",

pages = "8--19",

journal = "Aging Clinical and Experimental Research",

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T1 - Quantitative Trait Loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice

AU - Lang, Dean H.

AU - Gerhard, Glenn S.

AU - Griffith, James W.

AU - Vogler, George P.

AU - Vandenbergh, David J.

AU - Blizard, David A.

AU - Stout, Joseph T.

AU - Lakoski, Joan M.

AU - McClearn, Gerald E.

N1 - Funding Information: This work was supported by grants P01 AG14731 and training grant AG00276 from the National Institute on Aging of the National Institutes of Health.

PY - 2010/2

Y1 - 2010/2

N2 - Background and aims: Genes associated with longevity have been identified using both single gene and genome-wide approaches in a variety of species. The aim of this study was to identify quantitative trait loci (QTLs) that influence longevity in male and female mice from twenty-three C57BL/6J by DBA/2J (BXD) recombinant inbred (RI) strains. Methods: Approximately 12 animals of each sex for each RI strain were maintained under standard conditions until natural death or moribundity criteria were met. Results: A number of life span-relevant loci previously reported on chromosomes (Chrs) 7, 8, 10 and 11 were confirmed. In addition, 5 previously unreported QTLs for mouse life span on Chrs 1,2,6,11, and X were identified as significant and 3 QTLs on Chrs 5, 8, and 16 were suggestive. Conclusions: Several QTLs were coincident in males and females although the modest correlation between male and female median lifespans and the identification of sex specific QTLs provide evidence that the genetic architecture underlying longevity in the sexes may differ substantially. The identification of multiple QTLs for longevity will provide valuable resources for both reductionist and integrationist research into mechanisms of life span determination.

AB - Background and aims: Genes associated with longevity have been identified using both single gene and genome-wide approaches in a variety of species. The aim of this study was to identify quantitative trait loci (QTLs) that influence longevity in male and female mice from twenty-three C57BL/6J by DBA/2J (BXD) recombinant inbred (RI) strains. Methods: Approximately 12 animals of each sex for each RI strain were maintained under standard conditions until natural death or moribundity criteria were met. Results: A number of life span-relevant loci previously reported on chromosomes (Chrs) 7, 8, 10 and 11 were confirmed. In addition, 5 previously unreported QTLs for mouse life span on Chrs 1,2,6,11, and X were identified as significant and 3 QTLs on Chrs 5, 8, and 16 were suggestive. Conclusions: Several QTLs were coincident in males and females although the modest correlation between male and female median lifespans and the identification of sex specific QTLs provide evidence that the genetic architecture underlying longevity in the sexes may differ substantially. The identification of multiple QTLs for longevity will provide valuable resources for both reductionist and integrationist research into mechanisms of life span determination.

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Quantitative Trait Loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice

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