Quazepam and temazepam: Effects of short‐ and intermediate‐term use and withdrawal

Anthony Kales, Edward O. Bixler, Constantin R. Soldatos, Antonio Vela‐bueno, Judith A. Jacoby, Joyce D. Kales

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Two benzodiazepine hypnotics, one with an intermediate elimination t½ (temazepam, 15 mg) and the other with a long t½ (quazepam, 15 mg), were evaluated in 22‐ night sleep laboratory studies. The effectiveness and side effects of these benzodiazepines were assessed during short‐ and intermediate term use. Subjects were also assessed for the presence of rebound insomnia after abrupt withdrawal. Quazepam, 15 mg, was significantly effective in improving sleep both with short‐ and intermediate‐term use, but the effectiveness of temazepam was considerably less. Although temazepam was effective for maintaining sleep with short‐term use, there was rapid development of tolerance for this effect with intermediate‐term use. Temazepam did not produce any behavioral side effects during either drug condition. The only side effect associated with quazepam was a significant degree of daytime sleepiness. After its withdrawal, temazepam was associated with some sleep and mood disturbance on the first withdrawal night, whereas quazepam had carryover effectiveness. Clinical Pharmacology and Therapeutics (1986) 39, 345–352; doi:

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalClinical Pharmacology & Therapeutics
Issue number3
StatePublished - Mar 1986

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


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