Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium

Leah B. Casabianca; David An; Jayakumar K. Natarajan; John N. Alumasa; Paul D. Roepe; Christian Wolf; Angel C. De Dios

doi:10.1021/ic800440d

Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium

Leah B. Casabianca, David An, Jayakumar K. Natarajan, John N. Alumasa, Paul D. Roepe, Christian Wolf, Angel C. De Dios

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs the antiferromagnetically coupled μ-oxo dimer) of ferriprotoporphyrin(IX) as a function of pH. The pH dependence of this equilibrium is significantly altered by the addition of either chloroquine or quinine. Chloroquine promotes the μ-oxo dimer whereas quinine promotes the monomer.

Original language	English (US)
Pages (from-to)	6077-6081
Number of pages	5
Journal	Inorganic chemistry
Volume	47
Issue number	13
DOIs	https://doi.org/10.1021/ic800440d
State	Published - Jul 7 2008

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry
Inorganic Chemistry

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10.1021/ic800440d

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abstract = "Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs the antiferromagnetically coupled μ-oxo dimer) of ferriprotoporphyrin(IX) as a function of pH. The pH dependence of this equilibrium is significantly altered by the addition of either chloroquine or quinine. Chloroquine promotes the μ-oxo dimer whereas quinine promotes the monomer.",

author = "Casabianca, {Leah B.} and David An and Natarajan, {Jayakumar K.} and Alumasa, {John N.} and Roepe, {Paul D.} and Christian Wolf and {De Dios}, {Angel C.}",

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TY - JOUR

T1 - Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium

AU - Casabianca, Leah B.

AU - An, David

AU - Natarajan, Jayakumar K.

AU - Alumasa, John N.

AU - Roepe, Paul D.

AU - Wolf, Christian

AU - De Dios, Angel C.

PY - 2008/7/7

Y1 - 2008/7/7

N2 - Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs the antiferromagnetically coupled μ-oxo dimer) of ferriprotoporphyrin(IX) as a function of pH. The pH dependence of this equilibrium is significantly altered by the addition of either chloroquine or quinine. Chloroquine promotes the μ-oxo dimer whereas quinine promotes the monomer.

AB - Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs the antiferromagnetically coupled μ-oxo dimer) of ferriprotoporphyrin(IX) as a function of pH. The pH dependence of this equilibrium is significantly altered by the addition of either chloroquine or quinine. Chloroquine promotes the μ-oxo dimer whereas quinine promotes the monomer.

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EP - 6081

JO - Inorganic chemistry

JF - Inorganic chemistry

IS - 13

ER -

Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium

Abstract

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