Quorum sensing systems and persistence

Laura Fernandez-García, Lucia Blasco, Rocío Trastoy, Rodolfo García-Contreras, Thomas K. Wood, Maria Tomás

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


In order to control the clonal population's fitness to manage the expense of the resources by the community, it is not surprising that bacterial communities coordinate the formation of persister cells (bacterial subpopulations that survive stress conditions such as antibiotic or environmental threats). The development of these persister cells is linked to the activity of intercellular signaling molecules. Among them, we focus on acyl-homoserine lactone (AHL), the competence-stimulating peptide (CSP), indole (IND) and autoinducer-2 (AI-2), all involved in the quorum sensing systems activation in several pathogens. In this work, we will describe the action of these molecules related with quorum sensing systems in Gram positive Streptococcus mutans and Staphylococcus aureus and in Gram negative Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter spp. bacteria.

Original languageEnglish (US)
Title of host publicationImplication of Quorum Sensing System in Biofilm Formation and Virulence
PublisherSpringer Singapore
Number of pages11
ISBN (Electronic)9789811324291
ISBN (Print)9789811324284
StatePublished - Jan 28 2019

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Immunology and Microbiology
  • General Biochemistry, Genetics and Molecular Biology


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