Racial Difference in Cerebral Microbleed Burden among Ischemic Stroke Patients

Shima Shahjouei, Georgios Tsivgoulis, Mantinderpreet Singh, Michael McCormack, Nariman Noorbakhsh-Sabet, Nitin Goyal, Anne W. Alexandrov, Andrei V. Alexandrov, Ramin Zand

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background and Aims Data on the epidemiology of cerebral microbleeds (CMBs) among patients with ischemic stroke are limited. This study compared the number, associated factors, and topography of CMBs between African American and Caucasian ischemic stroke patients in the Mid-South United States. Method We evaluated consecutive ischemic stroke patients admitted to our tertiary stroke center, University of Tennessee Health Science Center, Memphis, Tennessee, in a two-year period. We analyzed T2*-weighted magnetic resonance images for the number, location, and topography of CMBs, as well as patients' demographic and clinical information. Results Among 760 ischemic stroke patients who were included (mean age was 62.1 ± 13.9 years, 51.4% men), 450 (59.2%) were African American. In comparison with Caucasians, African Americans were about five years younger (P =.000) and had a higher rate of hypertension (80.9% vs. 74.5%, P =.036). Similarly, African Americans had a higher prevalence of diabetes mellitus (P =.001). There was no significant difference between African-Americans and Caucasians in terms of CMBs presence and location. African Americans had a higher number of CMBs in comparison with Caucasians, but the difference was not significant. African Americans were more likely to have CMBs ≥5 (P =.047). Although African American stroke patients had a higher rate of large confluent white matter lesions, there was no significant racial difference regarding the rate and severity of deep white matter lesions. Conclusion We did not observe any differences between African American and Caucasian patients with ischemic stroke patients regarding the presence, number, and location of CMBs. However, our results suggested that the prevalence of multiple CMBs (CMBs ≥5) might be higher among African American stroke patients.

Original languageEnglish (US)
Pages (from-to)2680-2685
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number11
StatePublished - Nov 2017

All Science Journal Classification (ASJC) codes

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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