TY - JOUR
T1 - Racial differences in allelic distribution at the human pulmonary surfactant protein B gene locus (SP-B)
AU - Veletza, Stavroula V.
AU - Rogan, Peter K.
AU - TenHave, Tom
AU - Olowe, Samuel A.
AU - Floros, Joanna
N1 - Funding Information:
Keceived 27 Septeniber 1995; accepted 29 Februarv 1996. We thank Susan DiAngelo for excellent technical assistance. This work H ~ sSupported by National Institutes of Health grant NIH HL34788. Present address for Peter K. Rogan is Allegheny-Singer Research Institute, Pittsburgh, PA, USA. Address correspondence to Joanna Floros, PhD, Department of Cellular and Molecular-Physiology, The Pennsylvania State University, College of Medicine, 500 Universit) Drive, Hershey, PA 17033. USA.
PY - 1996
Y1 - 1996
N2 - Variable numbers of composite repetitive motifs are found if different individuals within intron 4 of the surfactant protein B (SP-B) gene (Brochem J. 1995;303:583). This study tests the hypothesis that the distribution of SP-B alleles differs among racial/ethnic groups. A total of 412 SP-B alleles were analyzed: 206 from Caucasian, 68 from African-American, and 138 from Nigerian individuals. Twelve groups of alleles (A-L) carrying 3 to 18 motifs were found. The distribution of the 12 alleles in the Caucasian group differs from that found in the Nigerian (p < .001) and African-American (p < .001) populations. The overall distribution of alleles between the African-American and the Nigerian populations were not statistically different. Specific alleles were also present in different proportions among the groups studied. For example, the most common allele (allele E) in all three populations is present at a significantly higher frequency in Caucasians than in the other two populations, but its frequency does not differ from the Nigerian and African-American groups. A less frequent allele, H, also differs significantly when Caucasians are compared with each of the other two populations, but the frequency of this allele is comparable between the African-American and Nigerian populations. To assess the importance of having comparable racial composition between the control and the case groups, a group of African-American with respiratory distress syndrome (RDS) (n = 40) was compared with the African-American and the Caucasian groups studied above. No significant difference was observed between the racially matched groups by a significant difference (p = .006) was observed between the racially mixed groups. The results indicate that the distribution of SP-B alleles differs between the racial groups but not between the ethnic groups studied. Thus, racial composition of the groups under study is important when considering whether particular alleles at this locus predispose to inherited disorders.
AB - Variable numbers of composite repetitive motifs are found if different individuals within intron 4 of the surfactant protein B (SP-B) gene (Brochem J. 1995;303:583). This study tests the hypothesis that the distribution of SP-B alleles differs among racial/ethnic groups. A total of 412 SP-B alleles were analyzed: 206 from Caucasian, 68 from African-American, and 138 from Nigerian individuals. Twelve groups of alleles (A-L) carrying 3 to 18 motifs were found. The distribution of the 12 alleles in the Caucasian group differs from that found in the Nigerian (p < .001) and African-American (p < .001) populations. The overall distribution of alleles between the African-American and the Nigerian populations were not statistically different. Specific alleles were also present in different proportions among the groups studied. For example, the most common allele (allele E) in all three populations is present at a significantly higher frequency in Caucasians than in the other two populations, but its frequency does not differ from the Nigerian and African-American groups. A less frequent allele, H, also differs significantly when Caucasians are compared with each of the other two populations, but the frequency of this allele is comparable between the African-American and Nigerian populations. To assess the importance of having comparable racial composition between the control and the case groups, a group of African-American with respiratory distress syndrome (RDS) (n = 40) was compared with the African-American and the Caucasian groups studied above. No significant difference was observed between the racially matched groups by a significant difference (p = .006) was observed between the racially mixed groups. The results indicate that the distribution of SP-B alleles differs between the racial groups but not between the ethnic groups studied. Thus, racial composition of the groups under study is important when considering whether particular alleles at this locus predispose to inherited disorders.
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U2 - 10.3109/01902149609046037
DO - 10.3109/01902149609046037
M3 - Article
C2 - 8872090
AN - SCOPUS:0029826070
SN - 0190-2148
VL - 22
SP - 489
EP - 494
JO - Experimental Lung Research
JF - Experimental Lung Research
IS - 4
ER -