TY - JOUR
T1 - Racial disparities in frozen embryo transfer success
AU - Heyward, Quetrell
AU - Walter, Jessica R.
AU - Alur-Gupta, Snigdha
AU - Lal, Arnav
AU - Berger, Dara S.
AU - Koelper, Nathanael
AU - Butts, Samantha F.
AU - Gracia, Clarisa R.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/12
Y1 - 2021/12
N2 - Purpose: To compare pregnancy and birth outcomes after frozen embryo transfers (FETs) among White, Black, and Asian women and evaluate the effect of patient, protocol, and cycle characteristics on success. Methods: A retrospective chart review identified women who underwent an autologous FET at an academic fertility center between January 2013 and March 2020. Results: White, Black, and Asian women completed 1,181 (71.7%), 230 (14.0%), and 235 (14.3%) cycles, respectively. Black women were significantly less likely to achieve a positive hCG level (AOR 0.66, 95% CI 0.49–0.90), clinical pregnancy (AOR 0.71, 95% CI 0.53–0.97), and live birth (AOR 0.65, 95% CI 0.47–0.89) compared to White women after adjusting for possible confounders. There were no differences in the aforementioned outcomes when looking at cycles completed by Asian versus White women. When comparing outcomes by endometrial preparation protocol, significant differences were seen amongst the three groups for live birth rates following natural cycle FETs (52.36%, 25.81%, and 44.19% for White, Black, and Asian women, respectively, p = 0.02), a difference not appreciated after programmed FETs. Conclusion: Black race is associated with significantly worse pregnancy and live birth rates following FET when compared to White race. Additionally, significant differences in live birth rates among White, Black, and Asian women exist following natural cycle FET versus programmed FET. These disparities in success are not only important for patient counseling, but also when determining management strategies to improve fertility rates among minority women.
AB - Purpose: To compare pregnancy and birth outcomes after frozen embryo transfers (FETs) among White, Black, and Asian women and evaluate the effect of patient, protocol, and cycle characteristics on success. Methods: A retrospective chart review identified women who underwent an autologous FET at an academic fertility center between January 2013 and March 2020. Results: White, Black, and Asian women completed 1,181 (71.7%), 230 (14.0%), and 235 (14.3%) cycles, respectively. Black women were significantly less likely to achieve a positive hCG level (AOR 0.66, 95% CI 0.49–0.90), clinical pregnancy (AOR 0.71, 95% CI 0.53–0.97), and live birth (AOR 0.65, 95% CI 0.47–0.89) compared to White women after adjusting for possible confounders. There were no differences in the aforementioned outcomes when looking at cycles completed by Asian versus White women. When comparing outcomes by endometrial preparation protocol, significant differences were seen amongst the three groups for live birth rates following natural cycle FETs (52.36%, 25.81%, and 44.19% for White, Black, and Asian women, respectively, p = 0.02), a difference not appreciated after programmed FETs. Conclusion: Black race is associated with significantly worse pregnancy and live birth rates following FET when compared to White race. Additionally, significant differences in live birth rates among White, Black, and Asian women exist following natural cycle FET versus programmed FET. These disparities in success are not only important for patient counseling, but also when determining management strategies to improve fertility rates among minority women.
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U2 - 10.1007/s10815-021-02348-1
DO - 10.1007/s10815-021-02348-1
M3 - Article
C2 - 34739643
AN - SCOPUS:85118594040
SN - 1058-0468
VL - 38
SP - 3069
EP - 3075
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
IS - 12
ER -