Radiation hybrid map of the porcine genome comprising 2035 EST loci

Anette Rink, Katie Eyer, Benjamin Roelofs, Kimberly J. Priest, Kathleen J. Sharkey-Brockmeier, Sudkamon Lekhong, Elif K. Karajusuf, Jason Bang, Martine Yerle, Denis Milan, Wan Sheng Liu, Craig W. Beattie

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The IMpRH7000-rad radiation hybrid panel was used to map 2035 expressed sequence tags (ESTs) at a minimum LOD score of 4.0. A total of 134 linkage groups covers 57,192 cR or 78% of the predicted size of the porcine and 71% of the human genome, respectively. Approximately 81% (1649) of the porcine ESTs were annotated against the NCBI nonredundant database; 1422 mapped in silico to a location in build 35.1 of the human genome sequence (HGS) and 1185 to a gene and location in build 35.1 HGS. The map revealed 40 major breaks in synteny (1.00e -25 and lower) with the human genome, 37 of which fall within a single chromosome. At this improved level of resolution and coverage, porcine chromosomes (SSC) 2, 5, 6, 7, 12, and 14 remain "gene-rich" and homologous to human chromosomes (HSA) 17, 19, and 22, while SSC 1, 8, 11, and X have been confirmed to correspond to the "gene-deserts" on HSA 18, 4, 13, and X.

Original languageEnglish (US)
Pages (from-to)878-885
Number of pages8
JournalMammalian Genome
Issue number8
StatePublished - Aug 2006

All Science Journal Classification (ASJC) codes

  • Genetics


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