TY - GEN
T1 - Raman based hepatocellular carcinoma biomarker detection
AU - Santiago-Cordoba, M. A.
AU - Romano, P. R.
AU - MacKay, A.
AU - Demirel, M. C.
PY - 2011
Y1 - 2011
N2 - Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum glycoprotein biomarker, alpha-fetoprotein (AFP) Carbohydrate binding proteins, such as lectins, can be used as diagnostic indicators for monitoring glycosylation changes during disease progression in hepatitis B virus (HBV) or hepatitis C virus (HCV) infected patients. We prepared surface-enhanced Raman spectroscopy (SERS) substrates, which provide controllable, well-organized nanoparticles on the surface, for the analysis of a fucose binding lectin AAL. The SERS based assay provides fast (10 s), and reproducible (5% variation) detection.
AB - Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum glycoprotein biomarker, alpha-fetoprotein (AFP) Carbohydrate binding proteins, such as lectins, can be used as diagnostic indicators for monitoring glycosylation changes during disease progression in hepatitis B virus (HBV) or hepatitis C virus (HCV) infected patients. We prepared surface-enhanced Raman spectroscopy (SERS) substrates, which provide controllable, well-organized nanoparticles on the surface, for the analysis of a fucose binding lectin AAL. The SERS based assay provides fast (10 s), and reproducible (5% variation) detection.
UR - http://www.scopus.com/inward/record.url?scp=84863577508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863577508&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2011.6090620
DO - 10.1109/IEMBS.2011.6090620
M3 - Conference contribution
C2 - 22255136
AN - SCOPUS:84863577508
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 3672
EP - 3675
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -
