Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report

R. Shapiro; M. L. Jordan; V. P. Scantlebury; J. J. Fung; C. Jensen; C. Vivas; J. McCauley; W. D. Irish; S. Mitchell; A. J. Demetris; P. Randhawa; A. Jain; A. Tzakis; T. R. Hakala; R. L. Simmons; T. E. Starzl

Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report

R. Shapiro
, M. L. Jordan
, V. P. Scantlebury
, J. J. Fung
, C. Jensen
, C. Vivas
, J. McCauley
, W. D. Irish
, S. Mitchell
, A. J. Demetris
, P. Randhawa
, A. Jain
, A. Tzakis
, T. R. Hakala
, R. L. Simmons
, T. E. Starzl

Research output: Contribution to journal › Article › peer-review

Abstract

FK 506 was used as a primary immunosuppressive agent in 125 cases of renal transplantation in a randomized trial comparing FK 506/prednisone with FK 506/azathioprine/prednisone. With a mean follow-up of 5.5 ± 2.5 months, there has been a 6-month actuarial patient survival of 99% and graft survival of 88%. There is no difference thus far between the two-drug and three-drug groups, although there may be less rejection and diabetes in the three-drug group. These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.

Original language	English (US)
Pages (from-to)	669-672
Number of pages	4
Journal	Transplantation proceedings
Volume	25
Issue number	1
State	Published - 1993

All Science Journal Classification (ASJC) codes

Surgery
Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Shapiro, R., Jordan, M. L., Scantlebury, V. P., Fung, J. J., Jensen, C., Vivas, C., McCauley, J., Irish, W. D., Mitchell, S., Demetris, A. J., Randhawa, P., Jain, A., Tzakis, A., Hakala, T. R., Simmons, R. L., & Starzl, T. E. (1993). Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report. Transplantation proceedings, 25(1), 669-672.

@article{a6a46d0104c54318867120a762e006f3,

title = "Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report",

abstract = "FK 506 was used as a primary immunosuppressive agent in 125 cases of renal transplantation in a randomized trial comparing FK 506/prednisone with FK 506/azathioprine/prednisone. With a mean follow-up of 5.5 ± 2.5 months, there has been a 6-month actuarial patient survival of 99\% and graft survival of 88\%. There is no difference thus far between the two-drug and three-drug groups, although there may be less rejection and diabetes in the three-drug group. These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.",

author = "R. Shapiro and Jordan, \{M. L.\} and Scantlebury, \{V. P.\} and Fung, \{J. J.\} and C. Jensen and C. Vivas and J. McCauley and Irish, \{W. D.\} and S. Mitchell and Demetris, \{A. J.\} and P. Randhawa and A. Jain and A. Tzakis and Hakala, \{T. R.\} and Simmons, \{R. L.\} and Starzl, \{T. E.\}",

year = "1993",

language = "English (US)",

volume = "25",

pages = "669--672",

journal = "Transplantation proceedings",

issn = "0041-1345",

publisher = "Elsevier Inc.",

number = "1",

}

Shapiro, R, Jordan, ML, Scantlebury, VP, Fung, JJ, Jensen, C, Vivas, C, McCauley, J, Irish, WD, Mitchell, S, Demetris, AJ, Randhawa, P, Jain, A, Tzakis, A, Hakala, TR, Simmons, RL & Starzl, TE 1993, 'Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report', Transplantation proceedings, vol. 25, no. 1, pp. 669-672.

TY - JOUR

T1 - Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation

T2 - Preliminary report

AU - Shapiro, R.

AU - Jordan, M. L.

AU - Scantlebury, V. P.

AU - Fung, J. J.

AU - Jensen, C.

AU - Vivas, C.

AU - McCauley, J.

AU - Irish, W. D.

AU - Mitchell, S.

AU - Demetris, A. J.

AU - Randhawa, P.

AU - Jain, A.

AU - Tzakis, A.

AU - Hakala, T. R.

AU - Simmons, R. L.

AU - Starzl, T. E.

PY - 1993

Y1 - 1993

N2 - FK 506 was used as a primary immunosuppressive agent in 125 cases of renal transplantation in a randomized trial comparing FK 506/prednisone with FK 506/azathioprine/prednisone. With a mean follow-up of 5.5 ± 2.5 months, there has been a 6-month actuarial patient survival of 99% and graft survival of 88%. There is no difference thus far between the two-drug and three-drug groups, although there may be less rejection and diabetes in the three-drug group. These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.

AB - FK 506 was used as a primary immunosuppressive agent in 125 cases of renal transplantation in a randomized trial comparing FK 506/prednisone with FK 506/azathioprine/prednisone. With a mean follow-up of 5.5 ± 2.5 months, there has been a 6-month actuarial patient survival of 99% and graft survival of 88%. There is no difference thus far between the two-drug and three-drug groups, although there may be less rejection and diabetes in the three-drug group. These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.

UR - https://www.scopus.com/pages/publications/0027419725

UR - https://www.scopus.com/pages/publications/0027419725#tab=citedBy

M3 - Article

C2 - 7679836

AN - SCOPUS:0027419725

SN - 0041-1345

VL - 25

SP - 669

EP - 672

JO - Transplantation proceedings

JF - Transplantation proceedings

IS - 1

ER -

Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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