Rapid Brain Meninges Surface Reconstruction with Layer Topology Guarantee

Peiyu Duan, Yuan Xue, Shuo Han, Lianrui Zuo, Aaron Carass, Caitlyn Bernhard, Savannah Hays, Peter A. Calabresi, Susan M. Resnick, James S. Duncan, Jerry L. Prince

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The meninges, located between the skull and brain, are composed of three membrane layers: the pia, the arachnoid, and the dura. Reconstruction of these layers can aid in studying volume differences between patients with neurodegenerative diseases and normal aging subjects. In this work, we use convolutional neural networks (CNNs) to reconstruct surfaces representing meningeal layer boundaries from magnetic resonance (MR) images. We first use the CNNs to predict the signed distance functions (SDFs) representing these surfaces while preserving their anatomical ordering. The marching cubes algorithm is then used to generate continuous surface representations; both the subarachnoid space (SAS) and the intracranial volume (ICY) are computed from these surfaces. The proposed method is compared to a state-of-the-art deformable model-based reconstruction method, and we show that our method can reconstruct smoother and more accurate surfaces using less computation time. Finally, we conduct experiments with volumetric analysis on both subjects with multiple sclerosis and healthy controls. For healthy and MS subjects, ICYs and SAS volumes are found to be significantly correlated to sex (p<0.01) and age (p≤0.03) changes, respectively.

Original languageEnglish (US)
Title of host publication2023 IEEE International Symposium on Biomedical Imaging, ISBI 2023
PublisherIEEE Computer Society
ISBN (Electronic)9781665473583
StatePublished - 2023
Event20th IEEE International Symposium on Biomedical Imaging, ISBI 2023 - Cartagena, Colombia
Duration: Apr 18 2023Apr 21 2023

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452


Conference20th IEEE International Symposium on Biomedical Imaging, ISBI 2023

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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