Rapid loss of nicotine-cholinergic receptor binding activity in the deafferented avian optic lobe

Nicholas Brecha; Andrew Francis; Nisson Schechter

doi:10.1016/0006-8993(79)90822-9

Rapid loss of nicotine-cholinergic receptor binding activity in the deafferented avian optic lobe

Nicholas Brecha, Andrew Francis, Nisson Schechter

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The levels of α-bungarotoxin (α-BuTX) sensitive receptor sites were investigated in the optic lobe after optic deafferentation in the neonatal and adult chicken. Within two days a 30% loss of α-BuTX binding sites per optic lobe is observed in the neonatal chick after enucleation. The results are similar with the adult chicken in experiments where the receptor binding activity is measured in the optic lobe and in the optic tectum after enucleation. The possibility that acetylcholine is a neurotransmitter in the vertebrate retinotectal pathway is discussed.

Original language	English (US)
Pages (from-to)	273-280
Number of pages	8
Journal	Brain research
Volume	167
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(79)90822-9
State	Published - May 11 1979

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(79)90822-9

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title = "Rapid loss of nicotine-cholinergic receptor binding activity in the deafferented avian optic lobe",

abstract = "The levels of α-bungarotoxin (α-BuTX) sensitive receptor sites were investigated in the optic lobe after optic deafferentation in the neonatal and adult chicken. Within two days a 30% loss of α-BuTX binding sites per optic lobe is observed in the neonatal chick after enucleation. The results are similar with the adult chicken in experiments where the receptor binding activity is measured in the optic lobe and in the optic tectum after enucleation. The possibility that acetylcholine is a neurotransmitter in the vertebrate retinotectal pathway is discussed.",

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AU - Francis, Andrew

AU - Schechter, Nisson

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N2 - The levels of α-bungarotoxin (α-BuTX) sensitive receptor sites were investigated in the optic lobe after optic deafferentation in the neonatal and adult chicken. Within two days a 30% loss of α-BuTX binding sites per optic lobe is observed in the neonatal chick after enucleation. The results are similar with the adult chicken in experiments where the receptor binding activity is measured in the optic lobe and in the optic tectum after enucleation. The possibility that acetylcholine is a neurotransmitter in the vertebrate retinotectal pathway is discussed.

AB - The levels of α-bungarotoxin (α-BuTX) sensitive receptor sites were investigated in the optic lobe after optic deafferentation in the neonatal and adult chicken. Within two days a 30% loss of α-BuTX binding sites per optic lobe is observed in the neonatal chick after enucleation. The results are similar with the adult chicken in experiments where the receptor binding activity is measured in the optic lobe and in the optic tectum after enucleation. The possibility that acetylcholine is a neurotransmitter in the vertebrate retinotectal pathway is discussed.

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JO - Brain research

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Rapid loss of nicotine-cholinergic receptor binding activity in the deafferented avian optic lobe

Abstract

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