Rapid, Noninvasive diagnosis of balamuthia mandrillaris encephalitis by a plasma-based next-generation sequencing test

Gautam Kalyatanda; Kenneth Rand; Martin S. Lindner; David K. Hong; Mehmet Sait Albayram; Jason Gregory; Jesse Kresak; Karim M.Ali Ibne; Jennifer R. Cope; Shantanu Roy; Joy M. Gary; Varalakshmi Reddy; Asim A. Ahmed

doi:10.1093/ofid/ofaa189

Rapid, Noninvasive diagnosis of balamuthia mandrillaris encephalitis by a plasma-based next-generation sequencing test

Gautam Kalyatanda, Kenneth Rand, Martin S. Lindner, David K. Hong, Mehmet Sait Albayram, Jason Gregory, Jesse Kresak, Karim M.Ali Ibne, Jennifer R. Cope, Shantanu Roy, Joy M. Gary, Varalakshmi Reddy, Asim A. Ahmed

Department of Neurology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cellfree DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.

Original language	English (US)
Article number	ofaa189
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	7
DOIs	https://doi.org/10.1093/ofid/ofaa189
State	Published - Jul 1 2020

All Science Journal Classification (ASJC) codes

Oncology
Infectious Diseases

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10.1093/ofid/ofaa189

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Kalyatanda, G., Rand, K., Lindner, M. S., Hong, D. K., Albayram, M. S., Gregory, J., Kresak, J., Ibne, K. M. A., Cope, J. R., Roy, S., Gary, J. M., Reddy, V., & Ahmed, A. A. (2020). Rapid, Noninvasive diagnosis of balamuthia mandrillaris encephalitis by a plasma-based next-generation sequencing test. Open Forum Infectious Diseases, 7(7), Article ofaa189. https://doi.org/10.1093/ofid/ofaa189

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title = "Rapid, Noninvasive diagnosis of balamuthia mandrillaris encephalitis by a plasma-based next-generation sequencing test",

abstract = "Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cellfree DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.",

author = "Gautam Kalyatanda and Kenneth Rand and Lindner, \{Martin S.\} and Hong, \{David K.\} and Albayram, \{Mehmet Sait\} and Jason Gregory and Jesse Kresak and Ibne, \{Karim M.Ali\} and Cope, \{Jennifer R.\} and Shantanu Roy and Gary, \{Joy M.\} and Varalakshmi Reddy and Ahmed, \{Asim A.\}",

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doi = "10.1093/ofid/ofaa189",

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AU - Kalyatanda, Gautam

AU - Rand, Kenneth

AU - Lindner, Martin S.

AU - Hong, David K.

AU - Albayram, Mehmet Sait

AU - Gregory, Jason

AU - Kresak, Jesse

AU - Ibne, Karim M.Ali

AU - Cope, Jennifer R.

AU - Roy, Shantanu

AU - Gary, Joy M.

AU - Reddy, Varalakshmi

AU - Ahmed, Asim A.

PY - 2020/7/1

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N2 - Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cellfree DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.

AB - Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cellfree DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.

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IS - 7

M1 - ofaa189

ER -

Rapid, Noninvasive diagnosis of balamuthia mandrillaris encephalitis by a plasma-based next-generation sequencing test

Abstract

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