TY - JOUR
T1 - Rapidly growing squamous cell carcinoma
AU - Billingsley, Elizabeth M.
AU - Davis, Nicole
AU - Helm, Klaus F.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1999/4
Y1 - 1999/4
N2 - Background: Squamous cell carcinoma (SCC) may present with a history of rapid growth. Although multiple subtypes have been described regarding histologic characteristics and etiology, the subset of rapidly growing squamous cell carcinomas (RGSCC) has not been described. Objective: To evaluate and describe the clinical and histologic characteristics of squamous cell carcinomas that grow rapidly. Methods: Recorded clinical data and biopsies of 26 lesions with a history of rapid growth and histologically diagnosed as SCC were reviewed. Results: Rapidly growing SCC occurred most commonly on the head and neck, followed by hands and extremities, and had an average duration of 7 weeks before diagnosis. The average size of the lesions was 1.29 cm and nearly 20% occurred in immunosuppressed patients. Conclusions: Some SCCs may grow rapidly. The reason for the rapid growth is not clear and several hypotheses are discussed including immunosuppression and viral etiology. These lesions should be treated aggressively as their behaviour and prognosis are not yet well described.
AB - Background: Squamous cell carcinoma (SCC) may present with a history of rapid growth. Although multiple subtypes have been described regarding histologic characteristics and etiology, the subset of rapidly growing squamous cell carcinomas (RGSCC) has not been described. Objective: To evaluate and describe the clinical and histologic characteristics of squamous cell carcinomas that grow rapidly. Methods: Recorded clinical data and biopsies of 26 lesions with a history of rapid growth and histologically diagnosed as SCC were reviewed. Results: Rapidly growing SCC occurred most commonly on the head and neck, followed by hands and extremities, and had an average duration of 7 weeks before diagnosis. The average size of the lesions was 1.29 cm and nearly 20% occurred in immunosuppressed patients. Conclusions: Some SCCs may grow rapidly. The reason for the rapid growth is not clear and several hypotheses are discussed including immunosuppression and viral etiology. These lesions should be treated aggressively as their behaviour and prognosis are not yet well described.
UR - http://www.scopus.com/inward/record.url?scp=0032905466&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032905466&partnerID=8YFLogxK
U2 - 10.1177/120347549900300406
DO - 10.1177/120347549900300406
M3 - Article
C2 - 10366393
AN - SCOPUS:0032905466
SN - 1203-4754
VL - 3
SP - 193
EP - 197
JO - Journal of Cutaneous Medicine and Surgery
JF - Journal of Cutaneous Medicine and Surgery
IS - 4
ER -