RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway

James R. Broach

doi:10.1016/0168-9525(91)90018-L

RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway

James R. Broach

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Abstract

Ras proteins in budding yeasts initially appeared to regulate initiation of the cell cycle in response to nutrient availability. More recent work, while clarifying the mechanisms of Ras-mediated signal transduction, bas undermined our notion of the signal Ras transmits. We now suspect that Ras helps to coordinate cellular metabolism and mass accumulation, but what Ras responds to is not clear.

Original language	English (US)
Pages (from-to)	28-33
Number of pages	6
Journal	Trends in Genetics
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/0168-9525(91)90018-L
State	Published - Jan 1991

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/0168-9525(91)90018-L

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title = "RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway",

abstract = "Ras proteins in budding yeasts initially appeared to regulate initiation of the cell cycle in response to nutrient availability. More recent work, while clarifying the mechanisms of Ras-mediated signal transduction, bas undermined our notion of the signal Ras transmits. We now suspect that Ras helps to coordinate cellular metabolism and mass accumulation, but what Ras responds to is not clear.",

author = "Broach, {James R.}",

note = "Funding Information: Acknowledgements I thank the current and former members of my lab for their thoughtful comments and stimulating discussions con-ceming the role of RAS in yeast. This work was supported by grant CA41086 from NIH.",

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N2 - Ras proteins in budding yeasts initially appeared to regulate initiation of the cell cycle in response to nutrient availability. More recent work, while clarifying the mechanisms of Ras-mediated signal transduction, bas undermined our notion of the signal Ras transmits. We now suspect that Ras helps to coordinate cellular metabolism and mass accumulation, but what Ras responds to is not clear.

AB - Ras proteins in budding yeasts initially appeared to regulate initiation of the cell cycle in response to nutrient availability. More recent work, while clarifying the mechanisms of Ras-mediated signal transduction, bas undermined our notion of the signal Ras transmits. We now suspect that Ras helps to coordinate cellular metabolism and mass accumulation, but what Ras responds to is not clear.

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RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway

Abstract

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