Reactive angioendotheliomatosis in association with a well-differentiated angiosarcoma

Loren E. Clarke, Kathleen G. Julian, Jennie T. Clarke, Michael D. Ioffreda

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A 55-year-old white female with a complex medical history including mixed connective tissue disease and peripheral vascular disease developed a group of red-purple papules on her proximal medial thigh that was followed, five months later, by the development of a large violaceous patch. She reported a history of radiation to this site (for melanoma) during her childhood. She was admitted to the hospital with a presumptive diagnosis of cellulitis, but failed to respond to antibiotics. A biopsy was performed and demonstrated a well-differentiated angiosarcoma arising in conjunction with reactive angioendotheliomatosis. Excision of the lesion was performed, and fifteen months of follow-up have shown no recurrence or metastasis.

Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalAmerican Journal of Dermatopathology
Issue number5
StatePublished - Oct 2005

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Dermatology


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