Real world evaluation of dual-zone ICD and CRT-D programming compared to single-zone programming: The ALTITUDE REDUCES study

F. Roosevelt Gilliam, David L. Hayes, John Boehmer, John Day, Paul A. Heidenreich, Milan Seth, Paul W. Jones, Kenneth M. Stein, Leslie A. Saxon

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Tachycardia Detection, ICD, CRT-D Devices, Appropriate and Inappropriate Shock. Introduction: We evaluated the frequency of appropriate and inappropriate shocks and survival in patients using dual-zone programming versus single-zone programming. Methods and Results: For the ALTITUDE REDUCES study, patients were followed for 1.6 ± 1.1 years. The 12-month incidence of any shock was lower for dual-versus single-zone programmed detection at rates 200 bpm (P < 0.001). Appropriate shock rates at 1 year were also lower with dual-zone programming in these rate intervals (single zone 9.1%, 5.4%, P < 0.001, dual zone 6.7%, 4.7%, P < 0.02). There were no detectable differences between single- and dual-zone shock incidence at detection rates ≥ 200 bpm (P = 0.14). Inappropriate shock incidence was less with dual- versus single-zone detection at all detect rates <200 bpm, but not at rates ≥200 bpm (P < 0.001, P = 0.37). The lowest risk of appropriate and inappropriate shock was associated with dual-zone programming and detection rates ≥200 bpm (2.1%). Dual-zone detection was associated with more nonsustained and diverted therapy episodes but these patients did not have an increased risk of death compared to patients with single-zone programming. Patients programmed to low detection rate, single-zone detection and shock-only therapy also had the highest preshock mortality risk (P = 0.05). Conclusions: Shock incidence is lowest with either single- or dual-zone detection ≥200 bpm. For detection rates <200 bpm, dual-zone programming is associated with a reduction in the incidence of total shocks, appropriate shocks, and inappropriate shocks.

Original languageEnglish (US)
Pages (from-to)1023-1029
Number of pages7
JournalJournal of cardiovascular electrophysiology
Issue number9
StatePublished - Sep 2011

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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