Abstract

REAP-2 is an interactive dose-response curve estimation tool for Robust and Efficient Assessment of drug Potency. It provides user-friendly dose-response curve estimation for in vitro studies and conducts statistical testing for model comparisons with a redesigned user interface. We also make a major update of the underlying estimation method with penalized beta regression, which demonstrates great reliability and accuracy in dose estimation and uncertainty quantification. In this note, we describe the method and implementation of REAP-2 with a highlight on potency estimation and drug comparison.

Original languageEnglish (US)
Article numbere219
JournalJournal of Clinical and Translational Science
Volume7
Issue number1
DOIs
StatePublished - Oct 13 2023

All Science Journal Classification (ASJC) codes

  • General Medicine

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