TY - JOUR
T1 - Recent clinical developments and rationale for combining targeted agents in non-small cell lung cancer (NSCLC)
AU - Belani, C. P.
AU - Goss, G.
AU - Blumenschein, G.
N1 - Funding Information:
Medical writing support was provided by Lisa Cheyne at ACUMED® (Tytherington, UK) and was funded by Pfizer Inc.
PY - 2012/5
Y1 - 2012/5
N2 - While chemotherapy has been the standard of care for patients with advanced non-small cell lung cancer (NSCLC), efforts have shifted toward evaluating novel targeted agents in an attempt to improve outcome. These targeted agents are directed toward key components in several signalling pathways such as vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), epidermal growth factor receptor (EGFR) and insulin-like growth factor 1 receptor (IGF-IR). There is also increasing interest in using combinations of targeted agents to inhibit more than one pathway; for example, inhibition of VEGFR. +. EGFR and VEGFR. +. PDGFR. +. EGFR. Further investigation is needed to identify the most appropriate combinations of these targeted agents in select patient subgroups, and to define optimal treatment doses to thereby achieve the best therapeutic index. This review outlines the rationale for combining targeted agents for the treatment of advanced NSCLC.
AB - While chemotherapy has been the standard of care for patients with advanced non-small cell lung cancer (NSCLC), efforts have shifted toward evaluating novel targeted agents in an attempt to improve outcome. These targeted agents are directed toward key components in several signalling pathways such as vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), epidermal growth factor receptor (EGFR) and insulin-like growth factor 1 receptor (IGF-IR). There is also increasing interest in using combinations of targeted agents to inhibit more than one pathway; for example, inhibition of VEGFR. +. EGFR and VEGFR. +. PDGFR. +. EGFR. Further investigation is needed to identify the most appropriate combinations of these targeted agents in select patient subgroups, and to define optimal treatment doses to thereby achieve the best therapeutic index. This review outlines the rationale for combining targeted agents for the treatment of advanced NSCLC.
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U2 - 10.1016/j.ctrv.2011.05.009
DO - 10.1016/j.ctrv.2011.05.009
M3 - Review article
C2 - 21715100
AN - SCOPUS:84857658325
SN - 0305-7372
VL - 38
SP - 173
EP - 184
JO - Cancer Treatment Reviews
JF - Cancer Treatment Reviews
IS - 3
ER -