TY - JOUR
T1 - Recent updates in the clinical use of platinum compounds for the treatment of lung, breast, and genitourinary tumors and myeloma
AU - Belani, Chandra
PY - 2004/12
Y1 - 2004/12
N2 - Platinum compounds have shown activity in a broad spectrum of human tumors in vitro and in vivo. The clinical utility of platinum agents in gynecologic and gastrointestinal cancers (particularly oxaliplatin in colorectal cancer) has been well documented and platinum agents continue to be evaluated in a variety of other cancers. Given preclinical evidence of synergy among some platinum compounds and new anticancer agents, clinical trials exploring platinum-based combination therapies may yield improved treatment for a variety of malignancies. Recent clinical data on new chemotherapeutic strategies for the treatment of lung, breast, and genitourinary cancers and myeloma will be presented in this review.
AB - Platinum compounds have shown activity in a broad spectrum of human tumors in vitro and in vivo. The clinical utility of platinum agents in gynecologic and gastrointestinal cancers (particularly oxaliplatin in colorectal cancer) has been well documented and platinum agents continue to be evaluated in a variety of other cancers. Given preclinical evidence of synergy among some platinum compounds and new anticancer agents, clinical trials exploring platinum-based combination therapies may yield improved treatment for a variety of malignancies. Recent clinical data on new chemotherapeutic strategies for the treatment of lung, breast, and genitourinary cancers and myeloma will be presented in this review.
UR - http://www.scopus.com/inward/record.url?scp=11344263608&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11344263608&partnerID=8YFLogxK
U2 - 10.1053/j.seminoncol.2004.11.005
DO - 10.1053/j.seminoncol.2004.11.005
M3 - Article
C2 - 15726531
AN - SCOPUS:11344263608
SN - 0093-7754
VL - 31
SP - 25
EP - 33
JO - Seminars in oncology
JF - Seminars in oncology
IS - SUPPL. 14
ER -
