Receptor Theory and the Ligand-Macromolecule Complex

Research output: Chapter in Book/Report/Conference proceedingChapter

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Abstract

The quantification of the interaction between a small molecule such as a drug or pollutant and a cellular macromolecule is called receptor theory and is often overlooked in modern molecular toxicology. The proper use of receptor theory can be used to examine structure–activity relationships and modifications of chemicals to fit the active site of the macromolecule. Thus, the basic tools of quantification and characterization of a bimolecular interaction is applicable to drug discovery as well as toxicology. The shape of the dose–response curve, the most important relationship examined in toxicology, is dictated by receptor theory. In this chapter, the approaches to examining the ligand-receptor complex, taking into account all assumptions and limitations, will be described.

Original languageEnglish (US)
Title of host publicationComprehensive Toxicology, Third Edition
Subtitle of host publicationVolume 1-15
PublisherElsevier
PagesV8-18-V8-43
Volume8
ISBN (Electronic)9780081006122
ISBN (Print)9780081006016
DOIs
StatePublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • General Agricultural and Biological Sciences
  • General Environmental Science

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