Recombinogenic targeting: A new approach to genomic analysis - A review

Cooduvalli S. Shashikant; Janet L. Carr; Jaya Bhargava; Kevin L. Bentley; Frank H. Ruddle

doi:10.1016/S0378-1119(98)00369-2

Recombinogenic targeting: A new approach to genomic analysis - A review

Cooduvalli S. Shashikant
, Janet L. Carr
, Jaya Bhargava
, Kevin L. Bentley
, Frank H. Ruddle

Animal Science

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Currently, recombinational cloning procedures based upon methods developed for yeast, Saccharomyces cerevisiae, are being exploited for targeted cloning and in-vivo modification of genomic clones. In this review, we will discuss the development of large-insert vectors, homologous recombination-based techniques for cloning and modification, and their application towards functional analysis of genes using transgenic mouse model systems.

Original language	English (US)
Pages (from-to)	9-20
Number of pages	12
Journal	Gene
Volume	223
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-1119(98)00369-2
State	Published - Nov 26 1998

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/S0378-1119(98)00369-2

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title = "Recombinogenic targeting: A new approach to genomic analysis - A review",

abstract = "Currently, recombinational cloning procedures based upon methods developed for yeast, Saccharomyces cerevisiae, are being exploited for targeted cloning and in-vivo modification of genomic clones. In this review, we will discuss the development of large-insert vectors, homologous recombination-based techniques for cloning and modification, and their application towards functional analysis of genes using transgenic mouse model systems.",

author = "Shashikant, \{Cooduvalli S.\} and \{L. Carr\}, Janet and Jaya Bhargava and Bentley, \{Kevin L.\} and Ruddle, \{Frank H.\}",

note = "Funding Information: This work is supported by NIH grant GM09966 to F.H.R. ",

year = "1998",

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T2 - A new approach to genomic analysis - A review

AU - Shashikant, Cooduvalli S.

AU - L. Carr, Janet

AU - Bhargava, Jaya

AU - Bentley, Kevin L.

AU - Ruddle, Frank H.

N1 - Funding Information: This work is supported by NIH grant GM09966 to F.H.R.

PY - 1998/11/26

Y1 - 1998/11/26

N2 - Currently, recombinational cloning procedures based upon methods developed for yeast, Saccharomyces cerevisiae, are being exploited for targeted cloning and in-vivo modification of genomic clones. In this review, we will discuss the development of large-insert vectors, homologous recombination-based techniques for cloning and modification, and their application towards functional analysis of genes using transgenic mouse model systems.

AB - Currently, recombinational cloning procedures based upon methods developed for yeast, Saccharomyces cerevisiae, are being exploited for targeted cloning and in-vivo modification of genomic clones. In this review, we will discuss the development of large-insert vectors, homologous recombination-based techniques for cloning and modification, and their application towards functional analysis of genes using transgenic mouse model systems.

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ER -

Recombinogenic targeting: A new approach to genomic analysis - A review

Abstract

All Science Journal Classification (ASJC) codes

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