Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex

Katherine Belov, Janine E. Deakin, Anthony T. Papenfuss, Michelle L. Baker, Sandra D. Melman, Hannah V. Siddle, Nicolas Gouin, David L. Goode, Tobias J. Sargeant, Mark D. Robinson, Matthew J. Wakefield, Shaun Mahony, Joseph G.R. Cross, Panayiotis V. Benos, Paul B. Samollow, Terence P. Speed, Jennifer A. Marshall Graves, Robert D. Miller

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used the Monodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC of birds. Here we show that the opossum MHC is gene dense and complex, as in humans, but shares more organizational features with non-mammals. The Class I genes have amplified within the Class II region, resulting in a unique Class I/II region. We present a model of the organization of the MHC in ancestral mammals and its elaboration during mammalian evolution. The opossum genome, together with other extant genomes, reveals the existence of an ancestral "immune supercomplex" that contained genes of both types of natural killer receptors together with antigen processing genes and MHC genes. Copyright:

Original languageEnglish (US)
Pages (from-to)317-328
Number of pages12
JournalPLoS biology
Volume4
Issue number3
DOIs
StatePublished - Mar 2006

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences

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