Abstract
Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair-associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta-analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 212-216 |
| Number of pages | 5 |
| Journal | Annals of Clinical and Translational Neurology |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2017 |
All Science Journal Classification (ASJC) codes
- General Neuroscience
- Clinical Neurology
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