TY - JOUR
T1 - Red Meat-derived heterocyclic amines increase risk of colon cancer
T2 - A population-based case-control study
AU - Helmus, Drew S.
AU - Thompson, Cheryl L.
AU - Zelenskiy, Svetlana
AU - Tucker, Thomas C.
AU - Li, Li
N1 - Funding Information:
We thank Carly Levin for efforts collecting data and Audrey Lynn for editorial comments on manuscript drafts. This work was supported by the Damon Runyon Cancer Research Foundation (award CI-8) and the National Cancer Institute, National Institutes of Health, Department of Health and Human Services (grant R01-CA136726).
PY - 2013
Y1 - 2013
N2 - Formation of mutagenic heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) is one pathway believed to drive the association of colon cancer with meat consumption. Limited data exist on the associations of individual HCAs and PAHs in red or white meat with colon cancer. Analyzing data from a validated meat preparation questionnaire completed by 1062 incident colon cancer cases and 1645 population controls from an ongoing case-control study, risks of colon cancer were estimated using unconditional logistic regression models, comparing the fourth to the first quartile of mutagen estimates derived from a CHARRED based food frequency questionnaire. Total dietary intake of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) [adjusted odds ratio (aOR) = 1.87, 95% confidence interval (CI) = 1.44-2.44, Ptrend < 0.0001], 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) (aOR = 1.68, 95% CI = 1.29-2.17, Ptrend = 0.001) and meat-derived mutagenic activity (aOR = 1.77, 95% CI = 1.36-2.30, Ptrend < 0.0001) were statistically significantly associated with colon cancer risk. Meat type specific analyses revealed statistically significant associations for red meat-derived MeIQx, DiMeIQx, and mutagenic activity but not for the same mutagens derived from white meat. Our study adds evidence supporting red meat-derived, but not white-meat derived HCAs and PAHs, as an important pathway for environmental colon cancer carcinogenesis.
AB - Formation of mutagenic heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) is one pathway believed to drive the association of colon cancer with meat consumption. Limited data exist on the associations of individual HCAs and PAHs in red or white meat with colon cancer. Analyzing data from a validated meat preparation questionnaire completed by 1062 incident colon cancer cases and 1645 population controls from an ongoing case-control study, risks of colon cancer were estimated using unconditional logistic regression models, comparing the fourth to the first quartile of mutagen estimates derived from a CHARRED based food frequency questionnaire. Total dietary intake of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) [adjusted odds ratio (aOR) = 1.87, 95% confidence interval (CI) = 1.44-2.44, Ptrend < 0.0001], 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) (aOR = 1.68, 95% CI = 1.29-2.17, Ptrend = 0.001) and meat-derived mutagenic activity (aOR = 1.77, 95% CI = 1.36-2.30, Ptrend < 0.0001) were statistically significantly associated with colon cancer risk. Meat type specific analyses revealed statistically significant associations for red meat-derived MeIQx, DiMeIQx, and mutagenic activity but not for the same mutagens derived from white meat. Our study adds evidence supporting red meat-derived, but not white-meat derived HCAs and PAHs, as an important pathway for environmental colon cancer carcinogenesis.
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U2 - 10.1080/01635581.2013.834945
DO - 10.1080/01635581.2013.834945
M3 - Article
C2 - 24168237
AN - SCOPUS:84888334728
SN - 0163-5581
VL - 65
SP - 1141
EP - 1150
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 8
ER -
