TY - JOUR
T1 - Reducing the Toxicity of Radiotherapy for Pancreatic Cancer with Magnetic Resonance-guided Radiotherapy
AU - Tchelebi, Leila T.
AU - Zaorsky, Nicholas G.
AU - Rosenberg, Jennifer C.
AU - Sharma, Navesh K.
AU - Tuanquin, Leonard C.
AU - MacKley, Heath B.
AU - Ellis, Rodney J.
N1 - Publisher Copyright:
© 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Pancreatic cancer is a highly fatal malignancy for which surgery is currently considered to be the only curative treatment. However, less than a quarter of patients have disease amenable to definitive surgical resection. Local treatment with radiation therapy is a promising alternative to surgery for those patients with unresectable disease. However, conventional radiation techniques with computed tomography (CT)-guided therapy have yielded disappointing results due to the inability to deliver ablative doses of ionizing radiation, while sparing the radiosensitive adjacent organs at risk. Magnetic resonance-guided radiotherapy (MRgRT) has emerged as an alternative to CT-guided radiation treatment which allows for the delivery of higher doses of radiation with low toxicity to surrounding structures. Further study into the use of MRgRT and dose escalation for locally advanced unresectable pancreatic cancer is needed.
AB - Pancreatic cancer is a highly fatal malignancy for which surgery is currently considered to be the only curative treatment. However, less than a quarter of patients have disease amenable to definitive surgical resection. Local treatment with radiation therapy is a promising alternative to surgery for those patients with unresectable disease. However, conventional radiation techniques with computed tomography (CT)-guided therapy have yielded disappointing results due to the inability to deliver ablative doses of ionizing radiation, while sparing the radiosensitive adjacent organs at risk. Magnetic resonance-guided radiotherapy (MRgRT) has emerged as an alternative to CT-guided radiation treatment which allows for the delivery of higher doses of radiation with low toxicity to surrounding structures. Further study into the use of MRgRT and dose escalation for locally advanced unresectable pancreatic cancer is needed.
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U2 - 10.1093/toxsci/kfaa021
DO - 10.1093/toxsci/kfaa021
M3 - Article
C2 - 32053201
AN - SCOPUS:85084271724
SN - 1096-6080
VL - 175
SP - 19
EP - 23
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 1
ER -
