Regional brain atrophy in cognitively intact adults with a single APOE ε4 allele

H. A. Wishart, A. J. Saykin, T. W. McAllister, L. A. Rabin, B. C. McDonald, L. A. Flashman, R. M. Roth, A. C. Mamourian, G. J. Tsongalis, C. H. Rhodes

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


OBJECTIVE: To determine whether cognitively intact adults with the APOE ε3/ε4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the ε3 allele. METHODS: Participants were healthy, cognitively intact, right-handed adults, age 19 to 80, who completed genotyping, neuropsychological testing, and MRI. Forty-nine participants had the ε3/ε3 genotype and 27 had the ε3/ε4 genotype. Gray matter data were analyzed using the general linear model as implemented in the Statistical Parametric Mapping package, adjusting for age and sex. RESULTS: The ε3/ε4 participants showed lower gray matter density than the ε3/ε3 participants in right medial temporal and bilateral frontotemporal regions as well as other areas. There were no regions in which ε3/ε4 participants showed higher gray matter density than ε3/ε3 participants. CONCLUSIONS: Regionally reduced gray matter density is detectable in cognitively intact adults with a single copy of the APOE ε4 allele.

Original languageEnglish (US)
Pages (from-to)1221-1224
Number of pages4
Issue number7
StatePublished - Oct 2006

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


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