Regional cerebral glucose utilization transiently increases during mild hypoxia

C. MacNeill, R. M. Bryan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Regional cerebral glucose utilization (rCMR(glu)) was studied during mild hypoxic hypoxia in awake free-ranging rats. Rats were prepared with chronic arterial and venous catheters and placed in individual chambers for 4 days to recover from surgery before the experiments. The catheters were accessible by passing them through the top of the chambers. Hypoxia was induced by filling the chambers with a gas mixture consisting of 11% O2 in a balance of N2. Regional CMR(glu) and physiological parameters were measured in normoxic controls and in rats that had been hypoxic for 2 and 17 min before beginning the measurements. Regional CMR(glu) was measured in 17 brain regions using [6-14C]glucose. P(a)O2 decreased from 88 mm Hg in the controls to ~ 40 mm Hg during hypoxia. In the early stages of hypoxia (2-12 min), rCMR(glu) increased ~ 10-25% above the control rates. In later stages of hypoxia (17-27 min), rCMR(glu) was not different from that in the normoxic controls. The increase in rCMR(glu) in the early hypoxia was not blocked by propranolol (1.4 mg/kg), indicating that beta-adrenergic receptors were not involved with the increase in rCMR(glu). It was concluded that mild hypoxia is associated with an increased rate of cerebral glucose utilization; however, the increase is transitory, with glucose utilization returning to control rates before 17 min.

Original languageEnglish (US)
Pages (from-to)495-501
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number4
StatePublished - 1988

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Regional cerebral glucose utilization transiently increases during mild hypoxia'. Together they form a unique fingerprint.

Cite this