TY - JOUR
T1 - Regional concentration of putative nicotinic-cholinergic receptor sites in human brain
AU - Volpe, Bruce T.
AU - Francis, Andrew
AU - Gazzaniga, Michael S.
AU - Schechter, Nisson
N1 - Funding Information:
Abbreviations: a-BuTX-o-bungarotoxin, CAT-choline acetyltransferase. ’ We thank Dr. Jakob Schmidt for providing native and ‘Y-o-bungarotoxin, Drs. Carol Petit0 and Donald Rawlinson for providing assistance in neuropathology, and Isidore Doroski for technical assistance. This research was supported by the Long Island Research Institute and the McKnight Foundation. Drs. Volpe, Francis, and Gazzaniga are at Cornell. and Dr. Schechter is at Stony Brook.
Funding Information:
1 This research was supported by National Institute of Neurological and Communicative Disorders and Stroke grant NS 13211, Research Scientist Development Award MH 05804 to Dr. Dement, and INSERM to Dr. Guilleminault. The authors are indebted to Jon Zirn. Paul Delashaw, and Victoria Neyman, AHT, for their valuable help. Information and reprint requests should be addressed to Dr. Foutz.
PY - 1979/12
Y1 - 1979/12
N2 - Various anatomically distinct regions from postmortem human brain were analyzed for α-bungarotoxin (α-BuTX) binding and choline acetyltransferase activity. There was a heterogeneous distribution of both α-BuTX and enzyme activity in the regions studied. Although levels of α-BuTX binding were lower than those reported in other mammalian brain studies, the relative regional concentration was, in general, similar to that of other mammals. High binding activity was noted in the mammillary body, uncus, colliculi, and cortex. Lowest activity was observed in the caudate nucleus and cerebellum. Choline acetyltransferase activities in parallel assays confirmed prior data in human brain.
AB - Various anatomically distinct regions from postmortem human brain were analyzed for α-bungarotoxin (α-BuTX) binding and choline acetyltransferase activity. There was a heterogeneous distribution of both α-BuTX and enzyme activity in the regions studied. Although levels of α-BuTX binding were lower than those reported in other mammalian brain studies, the relative regional concentration was, in general, similar to that of other mammals. High binding activity was noted in the mammillary body, uncus, colliculi, and cortex. Lowest activity was observed in the caudate nucleus and cerebellum. Choline acetyltransferase activities in parallel assays confirmed prior data in human brain.
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U2 - 10.1016/0014-4886(79)90217-6
DO - 10.1016/0014-4886(79)90217-6
M3 - Article
C2 - 114410
AN - SCOPUS:0018616411
SN - 0014-4886
VL - 66
SP - 737
EP - 744
JO - Experimental Neurology
JF - Experimental Neurology
IS - 3
ER -