Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints

Paul J. Wang; Andrew J. Saykin; Laura A. Flashman; Heather A. Wishart; Laura A. Rabin; Robert B. Santulli; Tara L. McHugh; John W. MacDonald; Alexander C. Mamourian

doi:10.1016/j.neurobiolaging.2005.09.035

Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints

Paul J. Wang, Andrew J. Saykin, Laura A. Flashman, Heather A. Wishart, Laura A. Rabin, Robert B. Santulli, Tara L. McHugh, John W. MacDonald, Alexander C. Mamourian

Department of Radiology

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

The goal of the present study was to determine if there are global or regionally specific decreases in callosal area in early Alzheimer's disease (AD) and mild cognitive impairment (MCI). In addition, this study examined the corpus callosum of healthy older adults who have subjective cognitive complaints (CC) but perform within normal limits on neuropsychological tests. We used a semi-automated procedure to examine the total and regional areas of the corpus callosum in 22 patients with early AD, 28 patients with amnestic MCI, 28 healthy older adults with cognitive complaints, and 50 demographically matched healthy controls (HC). The AD, MCI, and CC groups all showed a significant reduction of the posterior region (isthmus and splenium) relative to healthy controls. The AD group also had a significantly smaller overall callosum than the controls. The demonstration of callosal atrophy in older adults with cognitive complaints suggests that callosal changes occur very early in the dementing process, and that these earliest changes may be too subtle for detection by neuropsychological assessments, including memory tests.

Original language	English (US)
Pages (from-to)	1613-1617
Number of pages	5
Journal	Neurobiology of Aging
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/j.neurobiolaging.2005.09.035
State	Published - Nov 2006

All Science Journal Classification (ASJC) codes

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2005.09.035

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@article{553748bc917b4c6587432907be931366,

title = "Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints",

abstract = "The goal of the present study was to determine if there are global or regionally specific decreases in callosal area in early Alzheimer's disease (AD) and mild cognitive impairment (MCI). In addition, this study examined the corpus callosum of healthy older adults who have subjective cognitive complaints (CC) but perform within normal limits on neuropsychological tests. We used a semi-automated procedure to examine the total and regional areas of the corpus callosum in 22 patients with early AD, 28 patients with amnestic MCI, 28 healthy older adults with cognitive complaints, and 50 demographically matched healthy controls (HC). The AD, MCI, and CC groups all showed a significant reduction of the posterior region (isthmus and splenium) relative to healthy controls. The AD group also had a significantly smaller overall callosum than the controls. The demonstration of callosal atrophy in older adults with cognitive complaints suggests that callosal changes occur very early in the dementing process, and that these earliest changes may be too subtle for detection by neuropsychological assessments, including memory tests.",

author = "Wang, {Paul J.} and Saykin, {Andrew J.} and Flashman, {Laura A.} and Wishart, {Heather A.} and Rabin, {Laura A.} and Santulli, {Robert B.} and McHugh, {Tara L.} and MacDonald, {John W.} and Mamourian, {Alexander C.}",

note = "Funding Information: This project was supported in part by funding from the NIA (R01 AG19771), Alzheimer's Association (IIRG-94-133 and IIRG-99-1653, sponsored by the Hedco Foundation), a Richter Research Grant, the Hitchcock Foundation, the Ira DeCamp Foundation, and New Hampshire Hospital, Concord, NH. This report is derived from an undergraduate Senior Honors Thesis by Mr. Wang. The authors thank the staff of the DHMC MRI Center for their help as well as Leslie Baxter, Cheryl Brown, Kevin Carroll, Stephen Guerin, Sterling Johnson, Jessica Lilly, Chad Moritz, Katherine Nutter-Upham, Judith R. O{\textquoteright}Jile, Heather Pixley, Jennifer Ramirez, and Henry J. Riordan of the Brain Imaging Laboratory for their contributions to patient recruitment, assessment, and scanning.",

year = "2006",

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doi = "10.1016/j.neurobiolaging.2005.09.035",

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AU - Wang, Paul J.

AU - Saykin, Andrew J.

AU - Flashman, Laura A.

AU - Wishart, Heather A.

AU - Rabin, Laura A.

AU - Santulli, Robert B.

AU - McHugh, Tara L.

AU - MacDonald, John W.

AU - Mamourian, Alexander C.

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PY - 2006/11

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N2 - The goal of the present study was to determine if there are global or regionally specific decreases in callosal area in early Alzheimer's disease (AD) and mild cognitive impairment (MCI). In addition, this study examined the corpus callosum of healthy older adults who have subjective cognitive complaints (CC) but perform within normal limits on neuropsychological tests. We used a semi-automated procedure to examine the total and regional areas of the corpus callosum in 22 patients with early AD, 28 patients with amnestic MCI, 28 healthy older adults with cognitive complaints, and 50 demographically matched healthy controls (HC). The AD, MCI, and CC groups all showed a significant reduction of the posterior region (isthmus and splenium) relative to healthy controls. The AD group also had a significantly smaller overall callosum than the controls. The demonstration of callosal atrophy in older adults with cognitive complaints suggests that callosal changes occur very early in the dementing process, and that these earliest changes may be too subtle for detection by neuropsychological assessments, including memory tests.

AB - The goal of the present study was to determine if there are global or regionally specific decreases in callosal area in early Alzheimer's disease (AD) and mild cognitive impairment (MCI). In addition, this study examined the corpus callosum of healthy older adults who have subjective cognitive complaints (CC) but perform within normal limits on neuropsychological tests. We used a semi-automated procedure to examine the total and regional areas of the corpus callosum in 22 patients with early AD, 28 patients with amnestic MCI, 28 healthy older adults with cognitive complaints, and 50 demographically matched healthy controls (HC). The AD, MCI, and CC groups all showed a significant reduction of the posterior region (isthmus and splenium) relative to healthy controls. The AD group also had a significantly smaller overall callosum than the controls. The demonstration of callosal atrophy in older adults with cognitive complaints suggests that callosal changes occur very early in the dementing process, and that these earliest changes may be too subtle for detection by neuropsychological assessments, including memory tests.

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Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints

Abstract

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