Regioselective α-Monochlorination of N-protected-3-piperidones

Pradeep S. Chauhan; Max M. Majireck; Steven M. Weinreb

doi:10.3987/COM-11-S(P)23

Regioselective α-Monochlorination of N-protected-3-piperidones

Pradeep S. Chauhan, Max M. Majireck, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A direct procedure for regioselective α-monochlorination of various N-sulfonyl and N-acyl-protected-3-piperidones with N-chlorosuccinimide (NCS) and Amberlyst-15 ion exchange resin is reported which leads predominantly (or exclusively) to 4-chloro-3-piperidones in all cases.

Original language	English (US)
Pages (from-to)	577-585
Number of pages	9
Journal	Heterocycles
Volume	84
Issue number	1
DOIs	https://doi.org/10.3987/COM-11-S(P)23
State	Published - Dec 22 2011

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "A direct procedure for regioselective α-monochlorination of various N-sulfonyl and N-acyl-protected-3-piperidones with N-chlorosuccinimide (NCS) and Amberlyst-15 ion exchange resin is reported which leads predominantly (or exclusively) to 4-chloro-3-piperidones in all cases.",

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AU - Majireck, Max M.

AU - Weinreb, Steven M.

PY - 2011/12/22

Y1 - 2011/12/22

N2 - A direct procedure for regioselective α-monochlorination of various N-sulfonyl and N-acyl-protected-3-piperidones with N-chlorosuccinimide (NCS) and Amberlyst-15 ion exchange resin is reported which leads predominantly (or exclusively) to 4-chloro-3-piperidones in all cases.

AB - A direct procedure for regioselective α-monochlorination of various N-sulfonyl and N-acyl-protected-3-piperidones with N-chlorosuccinimide (NCS) and Amberlyst-15 ion exchange resin is reported which leads predominantly (or exclusively) to 4-chloro-3-piperidones in all cases.

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Regioselective α-Monochlorination of N-protected-3-piperidones

Abstract

All Science Journal Classification (ASJC) codes

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