Regulating life or death: Potential role of microRNA in rescue of the corpus luteum

Samar W. Maalouf; Wan Sheng Liu; Istvan Albert; Joy L. Pate

doi:10.1016/j.mce.2014.10.005

Regulating life or death: Potential role of microRNA in rescue of the corpus luteum

Samar W. Maalouf, Wan Sheng Liu, Istvan Albert, Joy L. Pate

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The role of miRNA in tissue biology has added a new level of understanding of gene regulation and function. The corpus luteum (CL) is a transitory endocrine gland; the dynamic nature of the CL makes it a candidate for regulation by miRNA. Rescue of the CL from luteolysis is essential for the maintenance of pregnancy in all eutherian mammals. Using next generation sequencing, we profiled miRNA expression in the bovine CL during maternal recognition of pregnancy. We identified 590 luteal miRNA, of which 544 were known and 46 were novel miRNAs. Fifteen (including 3 novel) miRNAs were differentially expressed between CL of pregnant vs. cyclic animals. Target analysis of the differentially expressed miRNA resulted in genes involved in regulating apoptosis and immune response, providing evidence that miRNAs regulate the intracellular pathways that lead to either luteal regression or survival.

Original language	English (US)
Pages (from-to)	78-88
Number of pages	11
Journal	Molecular and Cellular Endocrinology
Volume	398
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2014.10.005
State	Published - Dec 1 2014

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Endocrinology

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10.1016/j.mce.2014.10.005

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title = "Regulating life or death: Potential role of microRNA in rescue of the corpus luteum",

abstract = "The role of miRNA in tissue biology has added a new level of understanding of gene regulation and function. The corpus luteum (CL) is a transitory endocrine gland; the dynamic nature of the CL makes it a candidate for regulation by miRNA. Rescue of the CL from luteolysis is essential for the maintenance of pregnancy in all eutherian mammals. Using next generation sequencing, we profiled miRNA expression in the bovine CL during maternal recognition of pregnancy. We identified 590 luteal miRNA, of which 544 were known and 46 were novel miRNAs. Fifteen (including 3 novel) miRNAs were differentially expressed between CL of pregnant vs. cyclic animals. Target analysis of the differentially expressed miRNA resulted in genes involved in regulating apoptosis and immune response, providing evidence that miRNAs regulate the intracellular pathways that lead to either luteal regression or survival.",

author = "Maalouf, {Samar W.} and Liu, {Wan Sheng} and Istvan Albert and Pate, {Joy L.}",

note = "Funding Information: The authors express gratitude to Troy L. Ott, Manasi Manohar Kamat, and Sreelakshmi Vasudevan for facilitation of animal management and tissue collection. The authors also thank Ti-Cheng Chang and Zhihong Liu for advice in bioinformatics programs. This project was supported by Agriculture and Food Research Initiative Competitive Grant no. 2012-67015-30212 from the USDA National Institute of Food and Agriculture . Publisher Copyright: {\textcopyright} 2014 Elsevier Ireland Ltd.",

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doi = "10.1016/j.mce.2014.10.005",

language = "English (US)",

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AU - Liu, Wan Sheng

AU - Albert, Istvan

AU - Pate, Joy L.

N1 - Funding Information: The authors express gratitude to Troy L. Ott, Manasi Manohar Kamat, and Sreelakshmi Vasudevan for facilitation of animal management and tissue collection. The authors also thank Ti-Cheng Chang and Zhihong Liu for advice in bioinformatics programs. This project was supported by Agriculture and Food Research Initiative Competitive Grant no. 2012-67015-30212 from the USDA National Institute of Food and Agriculture . Publisher Copyright: © 2014 Elsevier Ireland Ltd.

PY - 2014/12/1

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N2 - The role of miRNA in tissue biology has added a new level of understanding of gene regulation and function. The corpus luteum (CL) is a transitory endocrine gland; the dynamic nature of the CL makes it a candidate for regulation by miRNA. Rescue of the CL from luteolysis is essential for the maintenance of pregnancy in all eutherian mammals. Using next generation sequencing, we profiled miRNA expression in the bovine CL during maternal recognition of pregnancy. We identified 590 luteal miRNA, of which 544 were known and 46 were novel miRNAs. Fifteen (including 3 novel) miRNAs were differentially expressed between CL of pregnant vs. cyclic animals. Target analysis of the differentially expressed miRNA resulted in genes involved in regulating apoptosis and immune response, providing evidence that miRNAs regulate the intracellular pathways that lead to either luteal regression or survival.

AB - The role of miRNA in tissue biology has added a new level of understanding of gene regulation and function. The corpus luteum (CL) is a transitory endocrine gland; the dynamic nature of the CL makes it a candidate for regulation by miRNA. Rescue of the CL from luteolysis is essential for the maintenance of pregnancy in all eutherian mammals. Using next generation sequencing, we profiled miRNA expression in the bovine CL during maternal recognition of pregnancy. We identified 590 luteal miRNA, of which 544 were known and 46 were novel miRNAs. Fifteen (including 3 novel) miRNAs were differentially expressed between CL of pregnant vs. cyclic animals. Target analysis of the differentially expressed miRNA resulted in genes involved in regulating apoptosis and immune response, providing evidence that miRNAs regulate the intracellular pathways that lead to either luteal regression or survival.

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Regulating life or death: Potential role of microRNA in rescue of the corpus luteum

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