Regulation and role of Par-4 in gastrointestinal tumors

Rosalyn B. Irby; Christina Leah B. Kline; Arun Sharma

doi:10.1007/978-3-030-80558-6_4

Regulation and role of Par-4 in gastrointestinal tumors

Rosalyn B. Irby
, Christina Leah B. Kline
, Arun Sharma

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cancers of the gastrointestinal (GI) tract are the second leading cause of cancer deaths worldwide for both sexes. These include esophageal cancers, gastric cancers, cholangiocarcinomas, cancers of the small bowel, and colorectal cancer. Of these, colorectal cancers account for almost half of the cancers of the GI tract. In a number of these cancers, Par-4 has been shown to play a negative role in the progression of cancer. Higher Par-4 activity has been shown to indicate a better prognosis, as, when activated, it causes apoptosis in the cancer cells, both locally and distally. However, many factors affect both the expression and the activity of Par-4 in GI cancer cells. This chapter details what is known about the role and regulation of Par-4 in tumors of the GI tract.

Original language	English (US)
Title of host publication	Tumor Suppressor Par-4
Subtitle of host publication	Role in Cancer and Other Diseases
Publisher	Springer International Publishing
Pages	59-68
Number of pages	10
ISBN (Electronic)	9783030805586
ISBN (Print)	9783030805579
DOIs	https://doi.org/10.1007/978-3-030-80558-6_4
State	Published - Jan 1 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

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10.1007/978-3-030-80558-6_4

Cite this

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title = "Regulation and role of Par-4 in gastrointestinal tumors",

abstract = "Cancers of the gastrointestinal (GI) tract are the second leading cause of cancer deaths worldwide for both sexes. These include esophageal cancers, gastric cancers, cholangiocarcinomas, cancers of the small bowel, and colorectal cancer. Of these, colorectal cancers account for almost half of the cancers of the GI tract. In a number of these cancers, Par-4 has been shown to play a negative role in the progression of cancer. Higher Par-4 activity has been shown to indicate a better prognosis, as, when activated, it causes apoptosis in the cancer cells, both locally and distally. However, many factors affect both the expression and the activity of Par-4 in GI cancer cells. This chapter details what is known about the role and regulation of Par-4 in tumors of the GI tract.",

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T1 - Regulation and role of Par-4 in gastrointestinal tumors

AU - Irby, Rosalyn B.

AU - Kline, Christina Leah B.

AU - Sharma, Arun

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Y1 - 2022/1/1

N2 - Cancers of the gastrointestinal (GI) tract are the second leading cause of cancer deaths worldwide for both sexes. These include esophageal cancers, gastric cancers, cholangiocarcinomas, cancers of the small bowel, and colorectal cancer. Of these, colorectal cancers account for almost half of the cancers of the GI tract. In a number of these cancers, Par-4 has been shown to play a negative role in the progression of cancer. Higher Par-4 activity has been shown to indicate a better prognosis, as, when activated, it causes apoptosis in the cancer cells, both locally and distally. However, many factors affect both the expression and the activity of Par-4 in GI cancer cells. This chapter details what is known about the role and regulation of Par-4 in tumors of the GI tract.

AB - Cancers of the gastrointestinal (GI) tract are the second leading cause of cancer deaths worldwide for both sexes. These include esophageal cancers, gastric cancers, cholangiocarcinomas, cancers of the small bowel, and colorectal cancer. Of these, colorectal cancers account for almost half of the cancers of the GI tract. In a number of these cancers, Par-4 has been shown to play a negative role in the progression of cancer. Higher Par-4 activity has been shown to indicate a better prognosis, as, when activated, it causes apoptosis in the cancer cells, both locally and distally. However, many factors affect both the expression and the activity of Par-4 in GI cancer cells. This chapter details what is known about the role and regulation of Par-4 in tumors of the GI tract.

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UR - https://www.scopus.com/pages/publications/85164869358#tab=citedBy

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M3 - Chapter

AN - SCOPUS:85164869358

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BT - Tumor Suppressor Par-4

PB - Springer International Publishing

ER -

Regulation and role of Par-4 in gastrointestinal tumors

Abstract

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