TY - JOUR
T1 - Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses
AU - Lüscher, Bernhard
AU - Keller, Cheryl A.
N1 - Funding Information:
We thank A.M. Craig, A. De Blas and S.J. Moss for communication of articles prior to the publication date. We thank Gong Chen and the members of the Lüscher Laboratory for critical reading and comments on the article. Research in the authors' laboratory is supported by National Institute of Health grants NS11070, MH62391, and MH60989.
PY - 2004/6
Y1 - 2004/6
N2 - Neural inhibition in the brain is mainly mediated by ionotropic γ-aminobutyric acid type A (GABAA) receptors. Different subtypes of these receptors, distinguished by their subunit composition, are either concentrated at postsynaptic sites where they mediate phasic inhibition or found at perisynaptic and extrasynaptic locations where they prolong phasic inhibition and mediate tonic inhibition, respectively. Of special interest are mechanisms that modulate the stability and function of postsynaptic GABA A receptor subtypes and that are implicated in functional plasticity of inhibitory transmission in the brain. We will summarize recent progress on the classification of synaptic versus extrasynaptic receptors, the molecular composition of the postsynaptic cytoskeleton, the function of receptor-associated proteins in trafficking of GABAA receptors to and from synapses, and their role in post-translational signaling mechanisms that modulate the stability, density, and function of GABAA receptors in the postsynaptic membrane.
AB - Neural inhibition in the brain is mainly mediated by ionotropic γ-aminobutyric acid type A (GABAA) receptors. Different subtypes of these receptors, distinguished by their subunit composition, are either concentrated at postsynaptic sites where they mediate phasic inhibition or found at perisynaptic and extrasynaptic locations where they prolong phasic inhibition and mediate tonic inhibition, respectively. Of special interest are mechanisms that modulate the stability and function of postsynaptic GABA A receptor subtypes and that are implicated in functional plasticity of inhibitory transmission in the brain. We will summarize recent progress on the classification of synaptic versus extrasynaptic receptors, the molecular composition of the postsynaptic cytoskeleton, the function of receptor-associated proteins in trafficking of GABAA receptors to and from synapses, and their role in post-translational signaling mechanisms that modulate the stability, density, and function of GABAA receptors in the postsynaptic membrane.
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U2 - 10.1016/j.pharmthera.2004.04.003
DO - 10.1016/j.pharmthera.2004.04.003
M3 - Review article
C2 - 15246246
AN - SCOPUS:3042818495
SN - 0163-7258
VL - 102
SP - 195
EP - 221
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 3
ER -