Regulation of human gonadotropins. VI. serum follicle stimulating and luteinizing hormone determinations in children

Peter A. Lee, A. Rees Midgley, Robert B. Jaffe

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To quantitate gonadotropins from the first year of life to maturity, serum levels of LH and FSH have been measured by radioimmunoassay in 315 children aged 6 months through 20 yr. All results were expressed in terms of 2nd- IRP-HMG, as mlU/ml followed by the standard error of the mean. Normal boys from age 1 through 10 had significantly lower levels of FSH (4.6 ±0.3) than girls (5.4±0.3), while LH levels did not differ significantly between boys and girls (2.8±0.2 vs. 2.7 ±0.2). There was a progressive increase in levels of both LH and FSH from ages 11 through 16 for boys and approximately ages 9 through 12 for girls. The rise of both hormones is earlier in girls than boys. Serum LH levels of postpubertal girls and boys were 3.5- and 2.7-fold higher than comparable levels in prepubertal age groups. FSH, compared in a similar fashion, rose 1.7-fold in girls and 1.6- fold in boys. When attempts were made to relate gonadotropin levels to pubertal development the initial appearance of the physical characteristics of puberty were not accompanied by a rise of LH or FSH in either girls or boys. Among girls, a significant rise of gonadotropins was present when pubescent girls after menarche were compared with those before menarche. Among boys, only the postpubertal group showed a significant increase over the preceding stage of development.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
StatePublished - 1970

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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