Regulation of ornithine decarboxylase

Anthony E. Pegg

    Research output: Contribution to journalShort surveypeer-review

    400 Scopus citations

    Abstract

    Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. The amount of ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to changes in polyamine levels. Susceptibility to tumor development is increased in transgenic mice expressing high levels of ODC and is decreased in mice with reduced ODC due to loss of one ODC allele or elevated expression of antizyme, a protein that stimulates ODC degradation. This review describes key factors that contribute to the regulation of ODC levels, which can occur at the levels of transcription, translation, and protein turnover.

    Original languageEnglish (US)
    Pages (from-to)14529-14532
    Number of pages4
    JournalJournal of Biological Chemistry
    Volume281
    Issue number21
    DOIs
    StatePublished - May 26 2006

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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